Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2052
Official Symbol:EPHX1
Other Aliases:EPHX|EPOX|MEH
See related:HGNC:3401|MIM:132810|HPRD:00581
Chromosome:1
Location:1q42.1
Gene Description:epoxide hydrolase 1, microsomal (xenobiotic)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0859
ORGANISM:human
Entrez Gene ID:2052
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.4 :: -1.4 :: 1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13849CBCerebellum14.307613372802716.1534557342529
13849CTXCerebral cortex22.95015907287617.5267772674561
13849HIPHippocampal region22.983770370483432.5941123962402
13849HPFHippocampal formation21.975276947021525.5300960540771
13849HYHypothalamus10.281887054443410.1440258026123
13849LSXLateral septal complex15.310050964355514.3842344284058
13849MBMidbrain7.7515783309936510.4631652832031
13849MYMedulla17.377120971679723.6356620788574
13849OLFOlfactory bulb22.445257186889618.0911521911621
13849PPons14.069572448730519.4145164489746
13849PALPallidum7.307040214538575.98482847213745
13849RHPRetrohippocampal region20.464361190795916.3471813201904
13849sAMYStriatum-like amygdalar nuclei25.83507537841819.1927547454834
13849STRStriatum23.713775634765616.3264198303223
13849STRdStriatum dorsal region24.937332153320316.4143905639648
13849STRvStriatum ventral region23.397869110107415.2648019790649
13849THThalamus8.5019569396972712.5666284561157
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2052GO:0004301IEAFunctionepoxide hydrolase activity
2052GO:0004301TASFunctionepoxide hydrolase activity
2052GO:0005783IEAComponentendoplasmic reticulum
2052GO:0005792IEAComponentmicrosome
2052GO:0006805IEAProcessxenobiotic metabolism
2052GO:0009636IEAProcessresponse to toxin
2052GO:0016020IEAComponentmembrane
2052GO:0016021IEAComponentintegral to membrane
2052GO:0016787IEAFunctionhydrolase activity
2052GO:0019439IEAProcessaromatic compound catabolism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2052HYEP_HUMANP07099IPR000073AB_hydrolase_1Alpha/beta hydrolase fold-1
2052HYEP_HUMANP07099IPR010497EH_NEpoxide hydrolase, N-terminal
2052HYEP_HUMANP07099IPR000639Epox_hydrolaseEpoxide hydrolase
2052HYEP_HUMANP07099IPR002410Peptidase_S33Peptidase S33, prolyl aminopeptidase
2052HYEP_HUMANP07099IPR000379Ser_estrsEsterase/lipase/thioesterase

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