Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2065
Official Symbol:ERBB3
Other Aliases:ErbB-3|HER3|MDA-BF-1|MGC88033|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
See related:HGNC:3431|MIM:190151|HPRD:01820
Chromosome:12
Location:12q13
Gene Description:v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0137
ORGANISM:human
Entrez Gene ID:2065
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:13867
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13867CBCerebellum1.904856324195861.97366952896118
13867CTXCerebral cortex2.70334744453431.90025901794434
13867HIPHippocampal region1.326341152191161.19008803367615
13867HPFHippocampal formation2.580794095993041.98444330692291
13867HYHypothalamus1.342660903930661.00252223014832
13867LSXLateral septal complex1.331487774848940.897632896900177
13867MBMidbrain1.9563741683961.70388329029083
13867MYMedulla3.868426084518433.56749701499939
13867OLFOlfactory bulb5.065368652343754.65774059295654
13867PPons1.84149456024171.54789578914642
13867PALPallidum1.852841615676881.40157127380371
13867RHPRetrohippocampal region5.077359199523933.33227109909058
13867sAMYStriatum-like amygdalar nuclei0.966063201427460.634174227714539
13867STRStriatum2.503306627273561.75304305553436
13867STRdStriatum dorsal region3.160272121429442.25085544586182
13867STRvStriatum ventral region1.824968099594121.23620283603668
13867THThalamus1.788321018218991.39205348491669
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2065GO:0000166IEAFunctionnucleotide binding
2065GO:0004872IEAFunctionreceptor activity
2065GO:0005006TASFunctionepidermal growth factor receptor activity
2065GO:0005515IPIFunctionprotein binding
2065GO:0005524IEAFunctionATP binding
2065GO:0005887TASComponentintegral to plasma membrane
2065GO:0006468TASProcessprotein amino acid phosphorylation
2065GO:0007165IDAProcesssignal transduction
2065GO:0007169IEAProcesstransmembrane receptor protein tyrosine kinase signaling pathway
2065GO:0016020IEAComponentmembrane
2065GO:0016740IEAFunctiontransferase activity
2065GO:0046982IDAFunctionprotein heterodimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3572NP_002175.1interleukin 6 signal transducer (gp130, oncostatin M receptor)HPRD02824
-5747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
-9542NP_053585.1neuregulin 2 isoform 3HPRD04821
NP_001973.19542-Neuregulin 2HPRD01820
NP_001973.15295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD01820
NP_001973.15747-FAKHPRD01820
NP_001973.13572-Interleukin 6 receptor, betaHPRD01820
NP_001973.12065NP_001973.1v-erb-b2 erythroblastic leukemia viral oncogene homolog 3HPRD01820
NP_001973.13732NP_002222.1CD82 antigen isoform 1HPRD09004
NP_001973.13732NP_002222.1CD82 antigen isoform 1HPRD01820
NP_001973.12886NP_005301.1growth factor receptor-bound protein 7HPRD03311
NP_001973.12886NP_005301.1growth factor receptor-bound protein 7HPRD01820
NP_001973.15999NP_005604.1regulator of G-protein signaling 4HPRD03947
NP_001973.15999NP_005604.1regulator of G-protein signaling 4HPRD01820
NP_001973.16654NP_005624.2son of sevenless homolog 1HPRD01681
NP_001973.16654NP_005624.2son of sevenless homolog 1HPRD01820
NP_001973.15753NP_005966.1PTK6 protein tyrosine kinase 6HPRD03594
NP_001973.15753NP_005966.1PTK6 protein tyrosine kinase 6HPRD01820
NP_001973.15036NP_006182.1proliferation-associated 2G4, 38kDaHPRD03685
NP_001973.15036NP_006182.1proliferation-associated 2G4, 38kDaHPRD01820
NP_001973.15036NP_006182.1proliferation-associated 2G4, 38kDaBIND54904
NP_001973.110728NP_006592.2unactive progesterone receptor, 23 kDHPRD06138
NP_001973.110728NP_006592.2unactive progesterone receptor, 23 kDHPRD01820
NP_001973.13084NP_039250.1neuregulin 1 isoform HRG-beta1HPRD00802
NP_001973.13084NP_039250.1neuregulin 1 isoform HRG-beta1HPRD01820
NP_001973.13084NP_039258.1neuregulin 1 isoform HRG-alphaBIND128128
NP_001973.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_001973.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD01820
NP_001973.14582P15941Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma...HPRD01152
NP_001973.14582P15941Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma...HPRD01820
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2065ERBB3_HUMANP21860IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
2065ERBB3_HUMANP21860IPR000494EGF_rcpt_LEGF receptor, L domain
2065ERBB3_HUMANP21860IPR006211Furin-likeFurin-like cysteine rich region
2065ERBB3_HUMANP21860IPR000719Prot_kinaseProtein kinase
2065ERBB3_HUMANP21860IPR001245Tyr_pkinaseTyrosine protein kinase
2065ERBB3_HUMANP21860IPR013695WAKWall-associated kinase

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