Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:210
Official Symbol:ALAD
Other Aliases:ALADH|MGC5057|PBGS
See related:HGNC:395|MIM:125270|HPRD:00504
Chromosome:9
Location:9q33.1
Gene Description:aminolevulinate, delta-, dehydratase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIP0260
ORGANISM:human
Entrez Gene ID:210
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:16172612
Addiction Drug:ALCOHOL
Addiction Drug Detail:Chronic alcohol use
Addiction Brain Area:Brain
Drug Effects:Upregulated
Fold Change:1.7::1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17025CBCerebellum22.470510482788119.0440979003906
17025CTXCerebral cortex100.050.1666488647461
17025HIPHippocampal region53.818367004394557.9114151000977
17025HPFHippocampal formation61.11170196533247.5362739562988
17025HYHypothalamus100.052.686164855957
17025LSXLateral septal complex100.070.8546829223633
17025MBMidbrain52.127323150634824.2817001342773
17025MYMedulla44.405342102050822.8210029602051
17025OLFOlfactory bulb100.064.7032928466797
17025PPons51.458988189697325.3189353942871
17025PALPallidum94.747817993164146.9428596496582
17025RHPRetrohippocampal region75.834732055664135.3085823059082
17025sAMYStriatum-like amygdalar nuclei100.041.3119125366211
17025STRStriatum89.495124816894539.4953880310059
17025STRdStriatum dorsal region69.537277221679728.7157535552979
17025STRvStriatum ventral region100.058.9957618713379
17025THThalamus88.137145996093844.9156341552734
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
210GO:0004655IEAFunctionporphobilinogen synthase activity
210GO:0004655TASFunctionporphobilinogen synthase activity
210GO:0006783IEAProcessheme biosynthesis
210GO:0006783TASProcessheme biosynthesis
210GO:0008270IEAFunctionzinc ion binding
210GO:0016829IEAFunctionlyase activity
210GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
210IPR001731AlaD_dehydrataseDelta-aminolevulinic acid dehydratase
210HEM2_HUMANP13716IPR001731AlaD_dehydrataseDelta-aminolevulinic acid dehydratase

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