Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2108
Official Symbol:ETFA
Other Aliases:EMA|GA2|MADD
See related:HGNC:3481|MIM:608053|HPRD:01979
Chromosome:15
Location:15q23-q25
Gene Description:electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0269
ORGANISM:human
Entrez Gene ID:2108
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.60
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
110842CBCerebellum19.369543075561550.0
110842CTXCerebral cortex28.991109848022524.9102172851562
110842HIPHippocampal region21.084283828735431.0327243804932
110842HPFHippocampal formation24.067508697509829.4000339508057
110842HYHypothalamus16.486373901367216.6833839416504
110842LSXLateral septal complex14.188710212707517.9514980316162
110842MBMidbrain24.933113098144529.6854038238525
110842MYMedulla24.912361145019540.6424674987793
110842OLFOlfactory bulb22.227849960327119.1287593841553
110842PPons29.54767990112341.6319389343262
110842PALPallidum20.527708053588923.5302448272705
110842RHPRetrohippocampal region28.164175033569327.710241317749
110842sAMYStriatum-like amygdalar nuclei13.948827743530315.5147247314453
110842STRStriatum14.369475364685113.2075510025024
110842STRdStriatum dorsal region13.759346008300811.9349203109741
110842STRvStriatum ventral region16.004570007324213.1829690933228
110842THThalamus25.004953384399426.6851005554199
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2108GO:0005739TASComponentmitochondrion
2108GO:0005759TASComponentmitochondrial matrix
2108GO:0006118IEAProcesselectron transport
2108GO:0009055TASFunctionelectron carrier activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2109NP_001976.1electron-transfer-flavoprotein, beta polypeptide isoform 1HPRD00557
NP_000117.12109-Electron transfer flavoprotein beta polypeptideHPRD01979
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2108ETFA_HUMANP13804IPR001308ETF_alphaElectron transfer flavoprotein, alpha subunit
2108ETFA_HUMANP13804IPR000049ETF_betaElectron transfer flavoprotein beta-subunit

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