Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2138
Official Symbol:EYA1
Other Aliases:BOP|BOR
See related:HGNC:3519|MIM:601653|HPRD:03388
Chromosome:8
Location:8q13.3
Gene Description:eyes absent homolog 1 (Drosophila)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0061
ORGANISM:human
Entrez Gene ID:2138
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:-0.59 :: 0.88 :: 0.75 :: 0.29 :: 2.33 :: -1.25 :: 0.18 :: 0.41 :: 1.01 :: 0.68
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14048CBCerebellum3.019085347652444.18254792690277
14048CTXCerebral cortex5.863068699836734.89665812253952
14048HIPHippocampal region11.724035739898713.7468619346619
14048HPFHippocampal formation9.8960886001586910.4735724925995
14048HYHypothalamus0.5734278410673140.631049916148186
14048LSXLateral septal complex0.437458440661430.600855775177479
14048MBMidbrain1.389007270336152.33114778995514
14048MYMedulla2.339069366455082.98568105697632
14048OLFOlfactory bulb10.65392279624949.7130081653595
14048PPons1.512541055679322.72583031654358
14048PALPallidum0.8589331433176990.751158997416496
14048RHPRetrohippocampal region7.020645260810855.99538743495941
14048sAMYStriatum-like amygdalar nuclei1.5550913810731.33325374126434
14048STRStriatum3.369036436080932.40796619653702
14048STRdStriatum dorsal region4.024886488914492.90289977192879
14048STRvStriatum ventral region2.308211848139761.46289490163326
14048THThalamus1.994637042284012.34940469264984
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2138GO:0000287IEAFunctionmagnesium ion binding
2138GO:0003824IEAFunctioncatalytic activity
2138GO:0004725IEAFunctionprotein tyrosine phosphatase activity
2138GO:0005634IEAComponentnucleus
2138GO:0006350IEAProcesstranscription
2138GO:0006355IEAProcessregulation of transcription, DNA-dependent
2138GO:0007275IEAProcessdevelopment
2138GO:0007605TASProcesssensory perception of sound
2138GO:0008152IEAProcessmetabolism
2138GO:0009653TASProcessmorphogenesis
2138GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6496NP_005404.1sine oculis homeobox homolog 3HPRD04756
-6495NP_005973.1sine oculis homeobox homolog 1HPRD03125
NP_000494.2--DachHPRD03388
NP_000494.2--G proteinsHPRD03388
NP_000494.26496-SIX 3HPRD03388
NP_000494.26495-Homeobox protein SIX1HPRD03388
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2138IPR005834Dehal_like_hydroHaloacid dehalogenase-like hydrolase
2138EYA1_HUMANQ99502IPR005834Dehal_like_hydroHaloacid dehalogenase-like hydrolase

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