Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:217
Official Symbol:ALDH2
Other Aliases:ALDH-E2|ALDHI|ALDM|MGC1806
See related:HGNC:404|MIM:100650|HPRD:00003
Chromosome:12
Location:12q24.2
Gene Description:aldehyde dehydrogenase 2 family (mitochondrial)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0055
ORGANISM:human
Entrez Gene ID:217
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:11261392
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11669CBCerebellum25.505281448364357.6651382446289
11669CTXCerebral cortex29.906143188476624.0618209838867
11669HIPHippocampal region18.556617736816423.9157772064209
11669HPFHippocampal formation24.918350219726626.8665523529053
11669HYHypothalamus16.302080154418914.8963403701782
11669LSXLateral septal complex9.5232343673706110.5484399795532
11669MBMidbrain13.423512458801315.1959390640259
11669MYMedulla31.619007110595750.543270111084
11669OLFOlfactory bulb10.50593090057377.84828901290894
11669PPons19.961442947387723.957052230835
11669PALPallidum11.81343746185312.753945350647
11669RHPRetrohippocampal region32.840873718261728.7060489654541
11669sAMYStriatum-like amygdalar nuclei15.139786720275915.9719114303589
11669STRStriatum13.595202445983912.3973245620728
11669STRdStriatum dorsal region13.023453712463411.7067918777466
11669STRvStriatum ventral region12.59601116180429.03756618499756
11669THThalamus15.391305923461916.6472072601318
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
217GO:0004029TASFunctionaldehyde dehydrogenase (NAD) activity
217GO:0004030TASFunctionaldehyde dehydrogenase [NAD(P)+] activity
217GO:0005739IEAComponentmitochondrion
217GO:0005975TASProcesscarbohydrate metabolism
217GO:0006066TASProcessalcohol metabolism
217GO:0008152IEAProcessmetabolism
217GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3329NP_002147.2chaperoninHPRD00318
NP_000681.13329-Heat shock 60 KD protein 1HPRD00003
NP_000681.13336NP_002148.1heat shock 10kDa protein 1 (chaperonin 10)HPRD02535
NP_000681.13336NP_002148.1heat shock 10kDa protein 1 (chaperonin 10)HPRD00003
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
217ALDH2_HUMANP05091IPR002086Ald_DHAldehyde dehydrogenase
217ALDH2_HUMANP05091IPR001484PyrokininPyrokinin

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