Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2181
Official Symbol:ACSL3
Other Aliases:ACS3|FACL3|PRO2194
See related:HGNC:3570|MIM:602371|HPRD:03845
Chromosome:2
Location:2q34-q35
Gene Description:acyl-CoA synthetase long-chain family member 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0320
ORGANISM:human
Entrez Gene ID:2181
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.56
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
50790CBCerebellum5.125565528869636.17343997955322
50790CTXCerebral cortex7.47801017761235.78407430648804
50790HIPHippocampal region7.922351360321048.56420993804932
50790HPFHippocampal formation6.426857948303226.21989440917969
50790HYHypothalamus0.4351896345615390.401066511869431
50790LSXLateral septal complex0.7280629277229310.672106623649597
50790MBMidbrain0.6690531969070430.764848947525024
50790MYMedulla2.036721944808962.12662577629089
50790OLFOlfactory bulb6.981314659118656.34029150009155
50790PPons1.409964323043822.18869519233704
50790PALPallidum1.846841335296631.68309783935547
50790RHPRetrohippocampal region3.84349441528322.89577889442444
50790sAMYStriatum-like amygdalar nuclei1.932027816772461.72980630397797
50790STRStriatum1.601365923881531.30753219127655
50790STRdStriatum dorsal region1.810841917991641.47038125991821
50790STRvStriatum ventral region1.060609698295590.707135021686554
50790THThalamus3.718349933624273.49820375442505
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2181GO:0000287IEAFunctionmagnesium ion binding
2181GO:0003824IEAFunctioncatalytic activity
2181GO:0004321TASFunctionfatty-acyl-CoA synthase activity
2181GO:0004467IEAFunctionlong-chain-fatty-acid-CoA ligase activity
2181GO:0006629IEAProcesslipid metabolism
2181GO:0006631IEAProcessfatty acid metabolism
2181GO:0008152IEAProcessmetabolism
2181GO:0016020IEAComponentmembrane
2181GO:0016021IEAComponentintegral to membrane
2181GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2181ACSL3_HUMANO95573IPR000873AMP-bindAMP-dependent synthetase and ligase

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