Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2185
Official Symbol:PTK2B
Other Aliases:CADTK|CAKB|FADK2|FAK2|PKB|PTK|PYK2|RAFTK
See related:HGNC:9612|MIM:601212|HPRD:03131
Chromosome:8
Location:8p21.1
Gene Description:PTK2B protein tyrosine kinase 2 beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0595
ORGANISM:human
Entrez Gene ID:2185
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:50646
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19229CBCerebellum8.7316806316375712.0978722572327
19229CTXCerebral cortex100.0100.0
19229HIPHippocampal region100.0100.0
19229HPFHippocampal formation100.0100.0
19229HYHypothalamus7.032080650329596.91668844223022
19229LSXLateral septal complex100.0100.0
19229MBMidbrain11.300437927246112.1815409660339
19229MYMedulla9.833607912063610.3751788139343
19229OLFOlfactory bulb100.0100.0
19229PPons9.7977920770645110.6375412940979
19229PALPallidum27.773252487182635.6593799591064
19229RHPRetrohippocampal region100.0100.0
19229sAMYStriatum-like amygdalar nuclei81.717382431030389.5735282897949
19229STRStriatum100.0100.0
19229STRdStriatum dorsal region100.0100.0
19229STRvStriatum ventral region100.0100.0
19229THThalamus69.736423492431679.4180202484131
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2185GO:0000166IEAFunctionnucleotide binding
2185GO:0004715TASFunctionnon-membrane spanning protein tyrosine kinase activity
2185GO:0004871NASFunctionsignal transducer activity
2185GO:0005515IPIFunctionprotein binding
2185GO:0005524IEAFunctionATP binding
2185GO:0005737TASComponentcytoplasm
2185GO:0005856IEAComponentcytoskeleton
2185GO:0006461TASProcessprotein complex assembly
2185GO:0006468TASProcessprotein amino acid phosphorylation
2185GO:0006915TASProcessapoptosis
2185GO:0006950TASProcessresponse to stress
2185GO:0007155NRProcesscell adhesion
2185GO:0007165TASProcesssignal transduction
2185GO:0007172TASProcesssignal complex formation
2185GO:0008284TASProcesspositive regulation of cell proliferation
2185GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5829BAA18998.1paxillin gammaHPRD03937
-2934NP_000168.1gelsolin isoform a precursorHPRD00674
-2934NP_000168.1gelsolin isoform a precursorHPRD00674
-3689NP_000202.1integrin beta chain, beta 2 precursorHPRD02506
-4867NP_000263.2nephrocystin isoform 1HPRD09524
-2903NP_000824.1N-methyl-D-aspartate receptor subunit 2A precursorHPRD00698
-2534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
-3716NP_002218.1janus kinase 1HPRD00992
-4067NP_002341.1v-yes-1 Yamaguchi sarcoma viral related oncogene homologHPRD01301
-4145NP_002369.2megakaryocyte-associated tyrosine kinase isoform bHPRD02496
-5777NP_002822.2protein tyrosine phosphatase, non-receptor type 6 isoform 1HPRD01475
-5921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00745
-5921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00745
-6850NP_003168.2spleen tyrosine kinaseHPRD02514
-9404NP_004802.1leupaxinHPRD05651
-9600NP_004901.1phosphatidylinositol transfer protein, membrane-associatedHPRD07497
-3717NP_004963.1Janus kinase 2HPRD00993
-3932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD01080
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-7409NP_005419.2vav 1 oncogeneHPRD01284
-10278NP_005855.1embryonal Fyn-associated substrate isoform 1HPRD09932
-7094NP_006280.2talin 1HPRD01726
-4739NP_006394.1neural precursor cell expressed, developmentally down-regulated 9 isoform 1HPRD11888
-6513NP_006507.1solute carrier family 2 (facilitated glucose transporter), member 1HPRD00683
-10672NP_006563.2guanine nucleotide binding protein (G protein), alpha 13HPRD05100
-9564NP_055382.1breast cancer anti-estrogen resistance 1HPRD04248
-7041NP_057011.2androgen receptor coactivator ARA55HPRD03831
-57605NP_065896.1phosphatidylinositol transfer protein, membrane-associated 2HPRD08335
-83394NP_112497.1PITPNM family member 3HPRD07498
-6464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_004094.3--FIP200HPRD03131
NP_004094.3--FIP200HPRD03131
NP_004094.3--PSGAPHPRD03131
NP_004094.3--PSGAPHPRD03131
NP_004094.3--RAP1HPRD03131
NP_004094.3--RAP1HPRD03131
NP_004094.36464-SHCHPRD03131
NP_004094.35921-RasGAPHPRD03131
NP_004094.36714-c-SrcHPRD03131
NP_004094.39564-CRK associated substrateHPRD03131
NP_004094.39564-p130CASHPRD03131
NP_004094.34739-Enhancer of filamentation 1HPRD03131
NP_004094.32534-FynHPRD03131
NP_004094.33932-LckHPRD03131
NP_004094.35829-PaxillinHPRD03131
NP_004094.37041-HIC5HPRD03131
NP_004094.37094-TalinHPRD03131
NP_004094.39404-LeupaxinHPRD03131
NP_004094.310278-Embryonal Fyn associated substrateHPRD03131
NP_004094.357605-NIR3HPRD03131
NP_004094.383394-NIR1HPRD03131
NP_004094.39600-NIR2HPRD03131
NP_004094.35777-SHP1HPRD03131
NP_004094.33716-Janus kinase 1HPRD03131
NP_004094.36850-SYKHPRD03131
NP_004094.35295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD03131
NP_004094.35295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD03131
NP_004094.310672-Guanine nucleotide binding protein, alpha 13HPRD03131
NP_004094.37409-VAV1HPRD03131
NP_004094.37535-ZAP70HPRD03131
NP_004094.37535-ZAP70HPRD03131
NP_004094.35781-SHP2HPRD03131
NP_004094.35781-SHP2HPRD03131
NP_004094.33689-Integrin beta 2HPRD03131
NP_004094.36513-Solute carrier family,member 1HPRD03131
NP_004094.34067-LynHPRD03131
NP_004094.35580-Protein kinase C deltaHPRD03131
NP_004094.35580-Protein kinase C deltaHPRD03131
NP_004094.32903-N-methyl D-aspartate receptor subunit 2AHPRD03131
NP_004094.34867-NephrocystinHPRD03131
NP_004094.33690-Integrin beta 3HPRD03131
NP_004094.33690-Integrin beta 3HPRD03131
NP_004094.33737-Potassium voltage gated channel subfamily A member 2HPRD03131
NP_004094.33737-Potassium voltage gated channel subfamily A member 2HPRD03131
NP_004094.33717-Janus kinase 2HPRD03131
NP_004094.34145-Csk homologous kinaseHPRD03131
NP_004094.32934-GelsolinHPRD03131
NP_004094.33718NP_000206.2Janus kinase 3HPRD02547
NP_004094.33718NP_000206.2Janus kinase 3HPRD03131
NP_004094.34867NP_000263.2nephrocystin isoform 1HPRD09524
NP_004094.34867NP_000263.2nephrocystin isoform 1HPRD03131
NP_004094.32885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD03131
NP_004094.32885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_004094.35782NP_002826.2protein tyrosine phosphatase, non-receptor type 12HPRD03131
NP_004094.35782NP_002826.2protein tyrosine phosphatase, non-receptor type 12HPRD02513
NP_004094.38853NP_003878.1development- and differentiation-enhancing factor 2HPRD03131
NP_004094.38853NP_003878.1development- and differentiation-enhancing factor 2HPRD04820
NP_004094.34162NP_006491.1melanoma cell adhesion moleculeHPRD03131
NP_004094.34162NP_006491.1melanoma cell adhesion moleculeHPRD01120
NP_004094.38470NP_066547.1sorbin and SH3 domain containing 2 isoform 2HPRD12473
NP_004094.38470NP_066547.1sorbin and SH3 domain containing 2 isoform 2HPRD03131
NP_004094.3155871NP_057853.1Tat--
NP_775268.18470AAC05508.1Homo sapiens Arg/Abl-interacting protein ArgBP2a (ArgBP2a) mRNA, complete cds.BIND199747
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2185IPR000299Band_4.1Band 4.1
2185IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
2185IPR005189Focal_ATFocal adhesion targeting region
2185IPR000719Prot_kinaseProtein kinase
2185IPR001245Tyr_pkinaseTyrosine protein kinase
2185IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
2185IPR013695WAKWall-associated kinase
2185FAK2_HUMANQ14289IPR000299Band_4.1Band 4.1
2185FAK2_HUMANQ14289IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
2185FAK2_HUMANQ14289IPR005189Focal_ATFocal adhesion targeting region
2185FAK2_HUMANQ14289IPR000719Prot_kinaseProtein kinase
2185FAK2_HUMANQ14289IPR001245Tyr_pkinaseTyrosine protein kinase
2185FAK2_HUMANQ14289IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
2185FAK2_HUMANQ14289IPR013695WAKWall-associated kinase

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