Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2202
Official Symbol:EFEMP1
Other Aliases:DHRD|DRAD|FBLN3|FBNL|FLJ35535|MGC111353|MLVT|S1-5
See related:HGNC:3218|MIM:601548|HPRD:03331
Chromosome:2
Location:2p16
Gene Description:EGF-containing fibulin-like extracellular matrix protein 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0852
ORGANISM:human
Entrez Gene ID:2202
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -2.9
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
216616CBCerebellum8.448602676391616.7503395080566
216616CTXCerebral cortex4.910027027130135.50894117355347
216616HIPHippocampal region6.799726486206059.7172737121582
216616HPFHippocampal formation8.6455469131469713.6755990982056
216616HYHypothalamus3.344509601593023.28828930854797
216616LSXLateral septal complex2.368475198745732.45997667312622
216616MBMidbrain3.729009151458745.27067613601685
216616MYMedulla9.9931373596191413.4007940292358
216616OLFOlfactory bulb7.752854824066169.13986778259277
216616PPons8.1082525253295911.4879560470581
216616PALPallidum3.915765047073364.99093866348267
216616RHPRetrohippocampal region12.116745948791519.4011287689209
216616sAMYStriatum-like amygdalar nuclei3.70464229583745.11855125427246
216616STRStriatum2.209214448928832.34946227073669
216616STRdStriatum dorsal region1.847879648208621.85514795780182
216616STRvStriatum ventral region2.481534481048582.11813187599182
216616THThalamus4.233172893524175.88183355331421
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2202GO:0005509IEAFunctioncalcium ion binding
2202GO:0005515IPIFunctionprotein binding
2202GO:0005578TASComponentextracellular matrix (sensu Metazoa)
2202GO:0007601TASProcessvisual perception
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND217687
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2202FBLN3_HUMANQ12805IPR000152Asx_hydroxyl_SAspartic acid and asparagine hydroxylation site
2202FBLN3_HUMANQ12805IPR000742EGF_3EGF-like, type 3
2202FBLN3_HUMANQ12805IPR001881EGF_Ca_bdEGF-like calcium-binding
2202FBLN3_HUMANQ12805IPR013091EGF_Ca_bd_2EGF calcium-binding
2202FBLN3_HUMANQ12805IPR006209EGF_likeEGF-like
2202FBLN3_HUMANQ12805IPR013032EGF_like_regEGF-like region
2202FBLN3_HUMANQ12805IPR001491ThrmbomodulnThrombomodulin

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