Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2247
Official Symbol:FGF2
Other Aliases:BFGF|FGFB|HBGH-2
See related:HGNC:3676|MIM:134920|HPRD:00622
Chromosome:4
Location:4q26-q27
Gene Description:fibroblast growth factor 2 (basic)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0159
ORGANISM:human
Entrez Gene ID:2247
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.96 :: 1.72 :: 1.10 :: 0.61 :: -1.01 :: -1.87 :: -0.79
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14173CBCerebellum12.68631839752213.3656797409058
14173CTXCerebral cortex32.60240936279322.7812385559082
14173HIPHippocampal region17.047517776489319.2487258911133
14173HPFHippocampal formation18.46154022216817.4963989257812
14173HYHypothalamus11.26284980773939.2990779876709
14173LSXLateral septal complex0.2306155711412430.176275208592415
14173MBMidbrain13.056314468383811.6567344665527
14173MYMedulla16.819286346435516.2088985443115
14173OLFOlfactory bulb20.932483673095714.5089454650879
14173PPons15.078978538513215.1843090057373
14173PALPallidum10.23073863983158.78225326538086
14173RHPRetrohippocampal region21.88668251037615.9307775497437
14173sAMYStriatum-like amygdalar nuclei5.634170532226563.92894959449768
14173STRStriatum9.278694152832036.31489276885986
14173STRdStriatum dorsal region8.187959671020515.59049224853516
14173STRvStriatum ventral region17.358734130859411.1164293289185
14173THThalamus14.373705863952611.5744009017944
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2247GO:0000074IEAProcessregulation of progression through cell cycle
2247GO:0000187TASProcessactivation of MAPK activity
2247GO:0001525IEAProcessangiogenesis
2247GO:0005515IPIFunctionprotein binding
2247GO:0005615TASComponentextracellular space
2247GO:0006935TASProcesschemotaxis
2247GO:0007165NASProcesssignal transduction
2247GO:0007265TASProcessRas protein signal transduction
2247GO:0007267NRProcesscell-cell signaling
2247GO:0007399TASProcessnervous system development
2247GO:0007517NRProcessmuscle development
2247GO:0008083IEAFunctiongrowth factor activity
2247GO:0008201IEAFunctionheparin binding
2247GO:0008283IEAProcesscell proliferation
2247GO:0008284TASProcesspositive regulation of cell proliferation
2247GO:0009887TASProcessorgan morphogenesis
2247GO:0030154IEAProcesscell differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2260NP_000595.1fibroblast growth factor receptor 1 isoform 1 precursorHPRD00634
-7448NP_000629.2vitronectin precursorHPRD01902
-2264NP_002002.2fibroblast growth factor receptor 4 isoform 1 precursorHPRD00625
-2719NP_004475.1glypican 3HPRD02074
-9982NP_005121.1fibroblast growth factor binding protein 1HPRD06371
-3339NP_005520.2heparan sulfate proteoglycan 2HPRD00804
-9672NP_055469.1syndecan 3HPRD01719
-2263NP_075261.1fibroblast growth factor receptor 2 isoform 5 precursorHPRD01492
NP_001997.3155871NP_057853.1Tat--
NP_001997.3155871NP_057853.1Tat--
NP_001997.3155871NP_057853.1Tat--
NP_001997.49672-Syndecan 3HPRD00622
NP_001997.42264-FGF receptor 4HPRD00622
NP_001997.45196-Platelet factor 4HPRD00622
NP_001997.42260-FGF receptor 1HPRD00622
NP_001997.42263-Fibroblast growth factor receptor 2HPRD00622
NP_001997.49982-Fibroblast growth factor binding protein 1HPRD00622
NP_001997.47448-VitronectinHPRD00622
NP_001997.43339-PerlecanHPRD00622
NP_001997.42719-Glypican 3HPRD00622
NP_001997.46128NP_000961.2ribosomal protein L6HPRD00622
NP_001997.46128NP_000961.2ribosomal protein L6HPRD04745
NP_001997.46223NP_001013.1ribosomal protein S19HPRD00622
NP_001997.46223NP_001013.1ribosomal protein S19HPRD04591
NP_001997.48829NP_003864.2neuropilin 1BIND217633
NP_001997.410563NP_006410.1chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)HPRD05513
NP_001997.410563NP_006410.1chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)HPRD00622
NP_001997.48539NP_006586.1apoptosis inhibitor 5HPRD16500
NP_001997.49702NP_055494.2translokinHPRD16261
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2247FGF2_HUMANP09038IPR002209GF_heparin_bdHeparin-binding growth factor/Fibroblast growth factor
2247FGF2_HUMANP09038IPR002348IL1_HBGFInterleukin 1/heparin-binding growth factor

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