Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:22866
Official Symbol:CNKSR2
Other Aliases:CNK2|KIAA0902|KSR2
See related:HGNC:19701|HPRD:06473
Chromosome:X
Location:Xp22.12
Gene Description:connector enhancer of kinase suppressor of Ras 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0052
ORGANISM:human
Entrez Gene ID:22866
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.61 :: -0.11 :: 0.64 :: 1.10 :: 1.06 :: 0.07 :: 0.43 :: 0.01 :: -0.17 :: 0.55
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
245684CBCerebellum6.141762733459477.05215311050415
245684CTXCerebral cortex11.84418201446538.73850345611572
245684HIPHippocampal region21.408767700195328.829719543457
245684HPFHippocampal formation15.376555442810118.493408203125
245684HYHypothalamus0.1910141706466670.214229911565781
245684LSXLateral septal complex0.00.0
245684MBMidbrain0.4120416939258580.692037522792816
245684MYMedulla0.8460127115249631.0688990354538
245684OLFOlfactory bulb8.452624320983896.46806812286377
245684PPons0.3710948824882510.557268083095551
245684PALPallidum0.2205579280853270.234769180417061
245684RHPRetrohippocampal region5.052132606506354.06338834762573
245684sAMYStriatum-like amygdalar nuclei0.5653586983680730.512402474880219
245684STRStriatum1.964791536331181.53019678592682
245684STRdStriatum dorsal region1.593752026557921.30035018920898
245684STRvStriatum ventral region5.49223423004153.76141357421875
245684THThalamus0.6115726232528691.11570239067078
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
22866GO:0005515IEAFunctionprotein binding
22866GO:0005737IEAComponentcytoplasm
22866GO:0009966IEAProcessregulation of signal transduction
22866GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
22866CNKR2_HUMANQ8WXI2IPR010599CNKSR2Connector enhancer of kinase suppressor of ras 2
22866CNKR2_HUMANQ8WXI2IPR001478PDZPDZ/DHR/GLGF
22866CNKR2_HUMANQ8WXI2IPR001849PHPleckstrin-like
22866CNKR2_HUMANQ8WXI2IPR001660SAMSterile alpha motif SAM
22866CNKR2_HUMANQ8WXI2IPR011510SAM_2Sterile alpha motif homology 2

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