Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2289
Official Symbol:FKBP5
Other Aliases:FKBP51|FKBP54|MGC111006|P54|PPIase|Ptg-10
See related:HGNC:3721|MIM:602623|HPRD:04019
Chromosome:6
Location:6p21.3-21.2
Gene Description:FK506 binding protein 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0342
ORGANISM:human
Entrez Gene ID:2289
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14229
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14229CBCerebellum100.0100.0
14229CTXCerebral cortex100.093.2459259033203
14229HIPHippocampal region83.8238983154297100.0
14229HPFHippocampal formation87.5790252685547100.0
14229HYHypothalamus40.010536193847727.8098373413086
14229LSXLateral septal complex83.221641540527355.7316741943359
14229MBMidbrain28.155778884887721.3459224700928
14229MYMedulla42.63848495483442.3608016967773
14229OLFOlfactory bulb100.090.0023193359375
14229PPons20.838174819946318.3253517150879
14229PALPallidum53.126903533935543.3500900268555
14229RHPRetrohippocampal region92.86914062577.9765243530273
14229sAMYStriatum-like amygdalar nuclei79.862106323242262.2016067504883
14229STRStriatum100.076.8489456176758
14229STRdStriatum dorsal region100.078.9302978515625
14229STRvStriatum ventral region100.089.5537261962891
14229THThalamus38.347194671630930.5648555755615
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2289GO:0003755IEAFunctionpeptidyl-prolyl cis-trans isomerase activity
2289GO:0005528TASFunctionFK506 binding
2289GO:0005634IEAComponentnucleus
2289GO:0006457TASProcessprotein folding
2289GO:0016853IEAFunctionisomerase activity
2289GO:0051082IEAFunctionunfolded protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3320NP_005339.1heat shock 90kDa protein 1, alphaHPRD00777
AAA86245.1---BIND295489
NP_004108.13320-HSP90AHPRD04019
NP_004108.15241NP_000917.2progesterone receptorHPRD07077
NP_004108.15241NP_000917.2progesterone receptorHPRD04019
NP_004108.16885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD04011
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2289FKBP5_HUMANQ13451IPR001179FKBP_PPIasePeptidylprolyl isomerase, FKBP-type
2289FKBP5_HUMANQ13451IPR001440TPR_1Tetratricopeptide TPR_1
2289FKBP5_HUMANQ13451IPR013105TPR_2Tetratricopeptide TPR_2
2289FKBP5_HUMANQ13451IPR013026TPR_regionTetratricopeptide region

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