Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2290
Official Symbol:FOXG1B
Other Aliases:BF1|FKH2|FKHL1|FKHL4|HBF-1|HFK1|QIN
See related:HGNC:3812|MIM:164874|HPRD:01283
Chromosome:14
Location:14q12-q13
Gene Description:forkhead box G1B
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0207
ORGANISM:human
Entrez Gene ID:2290
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15228CBCerebellum0.8089507669210431.05651596188545
15228CTXCerebral cortex3.891858190298082.7864049077034
15228HIPHippocampal region26.629374504089418.338315486908
15228HPFHippocampal formation21.288740158081114.1437530517578
15228HYHypothalamus0.3175743147730830.278850745409727
15228LSXLateral septal complex0.7963709831237790.629792675375938
15228MBMidbrain0.6807074248790740.424260303378105
15228MYMedulla0.3732838109135630.454486690461636
15228OLFOlfactory bulb3.897173821926122.96433657407761
15228PPons0.6676990091800690.848563343286514
15228PALPallidum0.4849908500909810.330418847501278
15228RHPRetrohippocampal region11.12058568000797.82678973674774
15228sAMYStriatum-like amygdalar nuclei1.908348917961121.27222847938538
15228STRStriatum4.202263891696932.71256023645401
15228STRdStriatum dorsal region4.393802702426912.94673630595207
15228STRvStriatum ventral region5.673459172248843.18641728162766
15228THThalamus0.5783828198909760.412018246948719
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2290GO:0003700IEAFunctiontranscription factor activity
2290GO:0005634IEAComponentnucleus
2290GO:0006350IEAProcesstranscription
2290GO:0006355IEAProcessregulation of transcription, DNA-dependent
2290GO:0007275IEAProcessdevelopment
2290GO:0007420TASProcessbrain development
2290GO:0043565IEAFunctionsequence-specific DNA binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3065NP_004955.2histone deacetylase 1HPRD03143
-7088NP_005068.2transducin-like enhancer protein 1HPRD02557
-7090NP_005069.1transducin-like enhancer protein 3HPRD02558
-3280NP_005515.1hairy and enhancer of split 1HPRD00770
-4086NP_005891.1Sma- and Mad-related protein 1HPRD03356
NP_005240.3--PLU1HPRD01283
NP_005240.33065-Histone deacetylase 1HPRD01283
NP_005240.33280-Transcription factor HES-1HPRD01283
NP_005240.37088-TLE1HPRD01283
NP_005240.37090-Transducin like enhancer of split 3HPRD01283
NP_005240.34086-SMAD1HPRD01283
NP_005240.32309NP_001446.1forkhead box O3ABIND130624
NP_005240.32308NP_002006.2forkhead box O1ABIND130625
NP_005240.34303NP_005929.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)BIND130622
NP_005240.310765NP_006609.2Jumonji, AT rich interactive domain 1B (RBP2-like)HPRD01283
NP_005240.310765NP_006609.2Jumonji, AT rich interactive domain 1B (RBP2-like)HPRD09251
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2290FOXGB_HUMANP55315IPR002952EggshellEggshell protein
2290FOXGB_HUMANP55315IPR013638Fork-head_NFork-head N-terminal
2290FOXGB_HUMANP55315IPR000694PRO_richProline-rich region
2290FOXGB_HUMANP55315IPR001766TF_Fork_headFork head transcription factor
2290FOXGB_HUMANP55315IPR006077Vinculin/cateninVinculin/alpha-catenin
2290FOXGC_HUMANQ14488IPR002952EggshellEggshell protein
2290FOXGC_HUMANQ14488IPR013638Fork-head_NFork-head N-terminal
2290FOXGC_HUMANQ14488IPR000694PRO_richProline-rich region
2290FOXGC_HUMANQ14488IPR001766TF_Fork_headFork head transcription factor
2290FOXGC_HUMANQ14488IPR006077Vinculin/cateninVinculin/alpha-catenin

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