Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:231
Official Symbol:AKR1B1
Other Aliases:ADR|ALDR1|AR|MGC1804
See related:HGNC:381|MIM:103880|HPRD:00071
Chromosome:7
Location:7q35
Gene Description:aldo-keto reductase family 1, member B1 (aldose reductase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0552
ORGANISM:human
Entrez Gene ID:231
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24192
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11677CBCerebellum25.104475975036669.5408420562744
11677CTXCerebral cortex62.277259826660251.5299415588379
11677HIPHippocampal region37.341695785522558.6400661468506
11677HPFHippocampal formation44.169202804565455.8333873748779
11677HYHypothalamus28.903323173522926.1843595504761
11677LSXLateral septal complex21.953493595123317.1956090927124
11677MBMidbrain27.508815765380932.0742540359497
11677MYMedulla34.020935058593848.2625427246094
11677OLFOlfactory bulb46.693511962890640.8071479797363
11677PPons34.789805412292544.5785274505615
11677PALPallidum24.777858734130925.469822883606
11677RHPRetrohippocampal region55.253494262695352.4665756225586
11677sAMYStriatum-like amygdalar nuclei28.847944259643622.9064674377441
11677STRStriatum30.240249633789123.2532691955566
11677STRdStriatum dorsal region30.456850051879923.6262526512146
11677STRvStriatum ventral region33.717851638793924.4327230453491
11677THThalamus23.124805450439522.230978012085
KARG Evidence 2
KARG ID:HOT0009
Entrez Gene ID:231
RefSeq ID:NM_001628
Position Information:-, Enhancer, 95302bp
Linkage Marker:rs1362985
Evidence Type:ASSOCIATION GENOME SCANNING
Evidence Name:PUBMED
Evidence ID:16091475
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
231GO:0004032TASFunctionaldehyde reductase activity
231GO:0005615TASComponentextracellular space
231GO:0005975TASProcesscarbohydrate metabolism
231GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
231ALDR_HUMANP15121IPR001395Aldo/ket_redAldo/keto reductase

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