Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:23236
Official Symbol:PLCB1
Other Aliases:FLJ45792|PI-PLC|PLC-154|PLC-I
See related:HGNC:15917|MIM:607120|HPRD:06177
Chromosome:20
Location:20p12
Gene Description:phospholipase C, beta 1 (phosphoinositide-specific)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0430
ORGANISM:human
Entrez Gene ID:23236
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24654
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18795CBCerebellum29.062407493591337.6669807434082
18795CTXCerebral cortex100.0100.0
18795HIPHippocampal region100.0100.0
18795HPFHippocampal formation100.0100.0
18795HYHypothalamus32.678308486938522.4015798568726
18795LSXLateral septal complex100.0100.0
18795MBMidbrain38.489181518554730.6567306518555
18795MYMedulla30.263210296630930.4655141830444
18795OLFOlfactory bulb100.0100.0
18795PPons21.129775047302218.1276144981384
18795PALPallidum71.912605285644565.8381061553955
18795RHPRetrohippocampal region100.0100.0
18795sAMYStriatum-like amygdalar nuclei100.097.1189613342285
18795STRStriatum100.0100.0
18795STRdStriatum dorsal region100.0100.0
18795STRvStriatum ventral region100.0100.0
18795THThalamus26.55059432983426.2805213928223
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
23236GO:0000074NASProcessregulation of progression through cell cycle
23236GO:0004435IEAFunctionphosphoinositide phospholipase C activity
23236GO:0004435NASFunctionphosphoinositide phospholipase C activity
23236GO:0004871IEAFunctionsignal transducer activity
23236GO:0005509IEAFunctioncalcium ion binding
23236GO:0005634NASComponentnucleus
23236GO:0005737IDAComponentcytoplasm
23236GO:0006629IEAProcesslipid metabolism
23236GO:0007242IEAProcessintracellular signaling cascade
23236GO:0016042IEAProcesslipid catabolism
23236GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-54822NP_060142.2transient receptor potential cation channel, subfamily M, member 7HPRD10418
NP_056007.1--TubulinHPRD06177
NP_056007.150855NP_058644.1partitioning defective-6 homolog alpha isoform 1BIND300865
NP_056007.156288NP_062565.2partitioning-defective protein 3 homologBIND300866
NP_056007.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
23236IPR000008C2C2
23236IPR001192PI_PLCPhosphoinositide-specific phospholipase C (PLC)
23236IPR000909PI_PLC_XPhosphatidylinositol-specific phospholipase C, X region
23236IPR001711PI_PLC_YPhosphatidylinositol-specific phospholipase C, Y domain
23236IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
23236PLCB1_HUMANQ9NQ66IPR000008C2C2
23236PLCB1_HUMANQ9NQ66IPR001192PI_PLCPhosphoinositide-specific phospholipase C (PLC)
23236PLCB1_HUMANQ9NQ66IPR000909PI_PLC_XPhosphatidylinositol-specific phospholipase C, X region
23236PLCB1_HUMANQ9NQ66IPR001711PI_PLC_YPhosphatidylinositol-specific phospholipase C, Y domain
23236PLCB1_HUMANQ9NQ66IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant

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