Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:23327
Official Symbol:NEDD4L
Other Aliases:FLJ33870|KIAA0439|RSP5|hNedd4-2
See related:HGNC:7728|MIM:606384|HPRD:05903
Chromosome:18
Location:18q21
Gene Description:neural precursor cell expressed, developmentally down-regulated 4-like
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0062
ORGANISM:human
Entrez Gene ID:23327
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.28 :: 0.39 :: 0.37 :: 0.47 :: 0.79 :: 0.57 :: 0.68 :: -0.85 :: -0.61 :: 0.39
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
83814CBCerebellum45.622362852096653.7020266056061
83814CTXCerebral cortex100.0100.0
83814HIPHippocampal region100.0100.0
83814HPFHippocampal formation100.0100.0
83814HYHypothalamus14.105588674545312.1549162864685
83814LSXLateral septal complex46.482959747314542.4636459350586
83814MBMidbrain17.261323690414417.4351983070374
83814MYMedulla8.302688837051399.43206661939621
83814OLFOlfactory bulb86.980617523193493.6031646728516
83814PPons12.24470794200912.5988742113113
83814PALPallidum26.178544998168928.6117362976074
83814RHPRetrohippocampal region94.247035980224693.5225067138672
83814sAMYStriatum-like amygdalar nuclei69.140338897705161.8513698577881
83814STRStriatum100.0100.0
83814STRdStriatum dorsal region100.0100.0
83814STRvStriatum ventral region100.0100.0
83814THThalamus56.533018112182652.6551666259766
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
23327GO:0004842NASFunctionubiquitin-protein ligase activity
23327GO:0005515IPIFunctionprotein binding
23327GO:0005622ICComponentintracellular
23327GO:0006814NASProcesssodium ion transport
23327GO:0006883NASProcesssodium ion homeostasis
23327GO:0007588NASProcessexcretion
23327GO:0010038IDAProcessresponse to metal ion
23327GO:0016567NASProcessprotein ubiquitination
23327GO:0016874IEAFunctionligase activity
23327GO:0017080IDAFunctionsodium channel regulator activity
23327GO:0030104NASProcesswater homeostasis
23327GO:0042176NASProcessregulation of protein catabolism
23327GO:0045807NASProcesspositive regulation of endocytosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
BAA23711.11488250NP_579908.1latent membrane protein 2ABIND128092
NP_056092.254602NP_061953.1Nedd4 family interacting protein 2HPRD17629
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
23327NED4L_HUMANQ96PU5IPR000008C2C2
23327NED4L_HUMANQ96PU5IPR000569HECTHECT
23327NED4L_HUMANQ96PU5IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
23327NED4L_HUMANQ96PU5IPR002349WWWW
23327NED4L_HUMANQ96PU5IPR001202WW_Rsp5_WWPWW/Rsp5/WWP

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