Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2335
Official Symbol:FN1
Other Aliases:CIG|DKFZp686F10164|DKFZp686H0342|DKFZp686I1370|DKFZp686O13149|FINC|FN|LETS|MSF
See related:HGNC:3778|MIM:135600|HPRD:00626
Chromosome:2
Location:2q34
Gene Description:fibronectin 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0185
ORGANISM:human
Entrez Gene ID:2335
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0384
ORGANISM:human
Entrez Gene ID:2335
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: 1.1 :: 1.7 :: -1.1 :: -1.5 :: -2.1
KARG Evidence 3
KARG ID:EVIM0452
ORGANISM:human
Entrez Gene ID:2335
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1 :: -1.7 :: -1.6 :: 1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14268CBCerebellum20.191849946975730.9625110626221
14268CTXCerebral cortex18.855075359344518.9799695014954
14268HIPHippocampal region18.5185093879723.2248969078064
14268HPFHippocampal formation28.765861511230538.9427976608276
14268HYHypothalamus13.777313470840514.8061907291412
14268LSXLateral septal complex15.867873191833517.9606485366821
14268MBMidbrain13.907397985458419.5201630592346
14268MYMedulla18.344613790512124.7815299034119
14268OLFOlfactory bulb39.797687530517638.6652956008911
14268PPons17.482273578643822.7138137817383
14268PALPallidum13.150653958320615.4477972984314
14268RHPRetrohippocampal region47.077713012695362.6857662200928
14268sAMYStriatum-like amygdalar nuclei13.865358829498315.5793571472168
14268STRStriatum14.077983617782614.8586945533752
14268STRdStriatum dorsal region13.245596885681214.2125267982483
14268STRvStriatum ventral region17.059944391250615.3814835548401
14268THThalamus14.494676113128718.603590965271
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2335GO:0005201NASFunctionextracellular matrix structural constituent
2335GO:0005518NASFunctioncollagen binding
2335GO:0005576IEAComponentextracellular region
2335GO:0005578NASComponentextracellular matrix (sensu Metazoa)
2335GO:0005793IDAComponentER-Golgi intermediate compartment
2335GO:0006953IEAProcessacute-phase response
2335GO:0007155NASProcesscell adhesion
2335GO:0007169NASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
2335GO:0008152IEAProcessmetabolism
2335GO:0008201NASFunctionheparin binding
2335GO:0009611NASProcessresponse to wounding
2335GO:0016477NASProcesscell migration
2335GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
--AAA26632.1S.aureus fibronectin-binding protein (fnbA) mRNA, and translated productsBIND259447
-2934NP_000168.1gelsolin isoform a precursorHPRD00674
-4653NP_000252.1myocilinHPRD03387
-5310NP_000287.2polycystin 1 isoform 2 precursorHPRD03203
-7045NP_000349.1transforming growth factor, beta-induced, 68kDaHPRD03409
-7253NP_000360.1thyroid stimulating hormone receptorHPRD04537
-6387NP_000600.1chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) isoform betaHPRD02904
-4052NP_000618.2latent transforming growth factor beta binding protein 1 isoform LTBP-1SHPRD01039
-3676NP_000876.1integrin alpha 4 precursorHPRD01894
-3695NP_000880.1integrin, beta 7HPRD00948
-3371NP_002151.1tenascin C (hexabrachion)HPRD01756
-3678NP_002196.1integrin alpha 5 precursorHPRD00627
-4099NP_002352.1myelin associated glycoprotein isoform a precursorHPRD01160
-4147NP_002371.2matrilin 2 precursorHPRD03660
-4856NP_002505.1nov precursorHPRD01291
-5549NP_002716.1proline arginine-rich end leucine-rich repeat protein precursorHPRD03556
-6423NP_003004.1secreted frizzled-related protein 2 precursorBIND218057
-7057NP_003237.1thrombospondin 1HPRD01765
-7356NP_003348.1secretoglobin, family 1A, member 1 (uteroglobin)HPRD01884
-3675NP_005492.1integrin alpha 3 isoform b, precursorHPRD05431
-4224NP_005579.1meprin A, alpha (PABA peptide hydrolase)HPRD02666
-4225NP_005916.1meprin A, betaHPRD02667
-8190NP_006524.1melanoma inhibitory activityHPRD03216
-90070NP_150593.1lacritin precursorHPRD06302
-116844NP_443204.1leucine-rich alpha-2-glycoprotein 1HPRD10056
-164656NP_705837.1transmembrane protease, serine 6HPRD10270
-4052NP_996826.1latent transforming growth factor beta binding protein 1 isoform LTBP-1LHPRD01039
NP_002017.1---BIND24818
NP_002017.1---BIND24816
NP_002017.1--Tenascin CHPRD00626
NP_002017.1---BIND24813
NP_002017.1---BIND24815
NP_002017.1---BIND24817
NP_002017.1--LRHGHPRD00626
NP_002017.1--FibrinHPRD00626
NP_002017.1---BIND24809
NP_002017.1-AAC83709.1Group A rotavirus strain Wa-attenuated NSP4 mRNA, complete cds.BIND169404
NP_002017.13695-Integrin beta-7HPRD00626
NP_002017.12934-GelsolinHPRD00626
NP_002017.14224-Meprin A alphaHPRD00626
NP_002017.14225-Meprin,beta subunitHPRD00626
NP_002017.14052-Latent TGF beta binding protein 1HPRD00626
NP_002017.15068-PAP1HPRD00626
NP_002017.15068-Pancreatic beta cell growth factorHPRD00626
NP_002017.13676-Integrin alpha 4HPRD00626
NP_002017.13678-Integrin alpha 5HPRD00626
NP_002017.17428-VHLHPRD00626
NP_002017.13675-Integrin alpha 3HPRD00626
NP_002017.17356-UteroglobinHPRD00626
NP_002017.16387-Stromal cell derived factor 1HPRD00626
NP_002017.18190-Melanoma derived growth regulatory proteinHPRD00626
NP_002017.190070-LacritinHPRD00626
NP_002017.14099-SIGLEC4AHPRD00626
NP_002017.15310-Polycystin 1HPRD00626
NP_002017.14653-MyocilinHPRD00626
NP_002017.17057-Thrombospondin IHPRD00626
NP_002017.15549-Proline arginine rich end Leucine rich repeat proteinHPRD00626
NP_002017.17045-Kerato-epithelinHPRD00626
NP_002017.17045-TGF beta induced, 68KDHPRD00626
NP_002017.17253-Thyroid stimulating hormone receptorHPRD00626
NP_002017.1164656-Transmembrane serine protease 6HPRD00626
NP_002017.14147-Matrilin 2HPRD00626
NP_002017.14856-NOVHPRD00626
NP_002017.17428NP_000542.1von Hippel-Lindau tumor suppressor isoform 1BIND13086
NP_002017.13486NP_000589.1insulin-like growth factor binding protein 3HPRD00626
NP_002017.13486NP_000589.1insulin-like growth factor binding protein 3HPRD00899
NP_002017.13694NP_000879.2integrin, beta 6HPRD00947
NP_002017.13694NP_000879.2integrin, beta 6HPRD00626
NP_002017.13486NP_001013416.1insulin-like growth factor binding protein 3 isoform a precursorHPRD00626
NP_002017.16383NP_002989.1syndecan 2HPRD00626
NP_002017.16383NP_002989.1syndecan 2HPRD00803
NP_002017.16383NP_002989.2syndecan 2 precursorHPRD00626
NP_002017.16863NP_003173.1tachykinin 1 isoform beta precursorHPRD08876
NP_002017.16863NP_003173.1tachykinin 1 isoform beta precursorHPRD00626
NP_002017.18516NP_003629.1integrin, alpha 8HPRD10361
NP_002017.18516NP_003629.1integrin, alpha 8HPRD00626
NP_002017.17052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD01825
NP_002017.17052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD00626
NP_002017.14318NP_004985.1matrix metalloproteinase 9 preproproteinHPRD00626
NP_002017.14318NP_004985.1matrix metalloproteinase 9 preproproteinHPRD00387
NP_002017.13959NP_005558.1galectin 3 binding proteinHPRD02796
NP_002017.13959NP_005558.1galectin 3 binding proteinHPRD00626
NP_002017.14018NP_005568.1lipoprotein, Lp(a)HPRD01063
NP_002017.14018NP_005568.1lipoprotein, Lp(a)HPRD00626
NP_002017.1155871NP_057853.1Tat--
NP_002017.1155871NP_057853.1Tat--
NP_002017.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2335IPR002086Ald_DHAldehyde dehydrogenase
2335IPR013032EGF_like_regEGF-like region
2335IPR000083Fibrnctn1Fibronectin, type I
2335IPR003962FnIII_subdFibronectin, type III subdomain
2335IPR003961FN_IIIFibronectin, type III
2335IPR000562FN_type2_col_bdType II fibronectin, collagen-binding
2335IPR001724Glyco_hydro_58Glycoside hydrolase, family 58
2335FINC_HUMANP02751IPR002086Ald_DHAldehyde dehydrogenase
2335FINC_HUMANP02751IPR013032EGF_like_regEGF-like region
2335FINC_HUMANP02751IPR000083Fibrnctn1Fibronectin, type I
2335FINC_HUMANP02751IPR003962FnIII_subdFibronectin, type III subdomain
2335FINC_HUMANP02751IPR003961FN_IIIFibronectin, type III
2335FINC_HUMANP02751IPR000562FN_type2_col_bdType II fibronectin, collagen-binding
2335FINC_HUMANP02751IPR001724Glyco_hydro_58Glycoside hydrolase, family 58

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