Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2353
Official Symbol:FOS
Other Aliases:c-fos
See related:HGNC:3796|MIM:164810|HPRD:01275
Chromosome:14
Location:14q24.3
Gene Description:v-fos FBJ murine osteosarcoma viral oncogene homolog
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0046
ORGANISM:human
Entrez Gene ID:2353
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14281
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0445
ORGANISM:human
Entrez Gene ID:2353
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:314322
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14281CBCerebellum51.705528259277361.9481620788574
14281CTXCerebral cortex60.993752797444764.3625946044922
14281HIPHippocampal region22.831684112548834.2784525553385
14281HPFHippocampal formation35.068240483601944.662109375
14281HYHypothalamus26.329727172851630.4057674407959
14281LSXLateral septal complex50.092763900756857.6741987864176
14281MBMidbrain29.068077087402331.7073129018148
14281MYMedulla15.955871264139818.5573383967082
14281OLFOlfactory bulb87.25237401326586.157351175944
14281PPons22.55713399251328.2378298441569
14281PALPallidum17.768383820851619.8845125834147
14281RHPRetrohippocampal region54.249333699544358.041389465332
14281sAMYStriatum-like amygdalar nuclei29.728383700052932.5222670237223
14281STRStriatum26.741717974344928.4503847757975
14281STRdStriatum dorsal region20.967032750447621.2128742535909
14281STRvStriatum ventral region38.381142934163440.0301342010498
14281THThalamus25.428964614868224.6552515029907
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2353GO:0003704TASFunctionspecific RNA polymerase II transcription factor activity
2353GO:0005634TASComponentnucleus
2353GO:0006306TASProcessDNA methylation
2353GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
2353GO:0006954TASProcessinflammatory response
2353GO:0043565IEAFunctionsequence-specific DNA binding
2353GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5925NP_000312.1retinoblastoma 1HPRD01574
-6927NP_000536.3transcription factor 1, hepaticHPRD00800
-2626NP_002043.2GATA binding protein 4HPRD08994
-3725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD01302
-3726NP_002220.1jun B proto-oncogeneHPRD01303
-6602NP_003067.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d1 isoform aHPRD03438
-6908NP_003185.1TATA box binding proteinHPRD02511
-7392NP_003358.1upstream stimulatory factor 2 isoform 1HPRD02668
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-4790NP_003989.1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)HPRD01238
-2963NP_004119.1general transcription factor IIF, polypeptide 2 (30kD subunit)HPRD01804
-6872NP_004597.2TBP-associated factor 1 isoform 1HPRD02436
-4094NP_005351.2v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform aHPRD01518
-9612NP_006303.1nuclear receptor co-repressor 2HPRD02910
-5371NP_150241.1promyelocytic leukemia protein isoform 1HPRD00023
-6885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD04011
K00650.16774--BIND300546
NC_000014.76722NP_003122.1serum response factor (c-fos serum response element-binding transcription factor)BIND196470
NM_005252.28570NP_003676.1KH-type splicing regulatory protein (FUSE binding protein 2)BIND144433
NP_005243.1--SAP-1aHPRD01275
NP_005243.1--B-ATFHPRD01275
NP_005243.1--FZA-BHPRD01275
NP_005243.1--T antigenHPRD01275
NP_005243.13726-Oncogene Jun-BHPRD01275
NP_005243.17392-Upstream stimulatory factor 2HPRD01275
NP_005243.13725-c JunHPRD01275
NP_005243.16908-TATA box binding proteinHPRD01275
NP_005243.16872-TFIIDHPRD01275
NP_005243.14094-c-MafHPRD01275
NP_005243.15925-Retinoblastoma 1HPRD01275
NP_005243.12963-TFIIF betaHPRD01275
NP_005243.14790-NFKB1HPRD01275
NP_005243.18648-SRC1HPRD01275
NP_005243.15371-PMLHPRD01275
NP_005243.19612-Nuclear receptor corepressor 2HPRD01275
NP_005243.16602-SMARCD1HPRD01275
NP_005243.16927-Transcription factor 1HPRD01275
NP_005243.16885-MAP3K7HPRD01275
NP_005243.14286BAA32288.1A-type microphthalmia associated transcription factorHPRD01275
NP_005243.14286BAA32288.1A-type microphthalmia associated transcription factorHPRD01138
NP_005243.17494BAB82982.1X box-binding protein spliced formHPRD01275
NP_005243.17494BAB82982.1X box-binding protein spliced formHPRD01908
NP_005243.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologBIND153133
NP_005243.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologBIND145576
NP_005243.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD04677
NP_005243.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD01275
NP_005243.13727NP_005345.2jun D proto-oncogeneHPRD01304
NP_005243.13727NP_005345.2jun D proto-oncogeneHPRD01275
NP_005243.110538NP_006390.1basic leucine zipper transcription factor, ATF-likeHPRD09820
NP_005243.110538NP_006390.1basic leucine zipper transcription factor, ATF-likeHPRD01275
NP_005243.125920NP_056271.2cofactor of BRCA1HPRD10845
NP_005243.15970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND145577
NP_005243.14773NP_775114.1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform CHPRD01275
NP_005243.14773NP_775114.1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 isoform CHPRD02730
NP_005243.1155871NP_057853.1Tat--
NP_005243.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2353FOS_HUMANP01100IPR011616bZIP_1bZIP transcription factor, bZIP_1
2353FOS_HUMANP01100IPR011700bZIP_2Basic leucine zipper
2353FOS_HUMANP01100IPR000837Leuzip_FosFos transforming protein
2353FOS_HUMANP01100IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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