Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2354
Official Symbol:FOSB
Other Aliases:G0S3|GOS3|GOSB|MGC42291
See related:HGNC:3797|MIM:164772|HPRD:01270
Chromosome:19
Location:19q13.32
Gene Description:FBJ murine osteosarcoma viral oncogene homolog B
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0217
ORGANISM:human
Entrez Gene ID:2354
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14282
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0404
ORGANISM:human
Entrez Gene ID:2354
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:308411
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIM0419
ORGANISM:human
Entrez Gene ID:2354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.1 :: -1.6 :: -1.4 :: -1.4 :: -1.4 :: -1.4
KARG Evidence 4
KARG ID:EVIM0487
ORGANISM:human
Entrez Gene ID:2354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.1 :: -1.3 :: -2.1 :: -1.3
KARG Evidence 5
KARG ID:EVID0012
ORGANISM:human
Entrez Gene ID:2354
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:164772
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14282CBCerebellum21.140958786010729.1285762786865
14282CTXCerebral cortex36.813747406005932.4934844970703
14282HIPHippocampal region16.297145843505922.067684173584
14282HPFHippocampal formation24.574924468994127.9451885223389
14282HYHypothalamus4.736381053924564.27808427810669
14282LSXLateral septal complex7.759287834167488.58390617370605
14282MBMidbrain4.75612401962284.54554748535156
14282MYMedulla3.694461822509773.80460858345032
14282OLFOlfactory bulb55.554767608642659.0144157409668
14282PPons4.443771362304694.81338500976562
14282PALPallidum7.747545719146737.40283298492432
14282RHPRetrohippocampal region36.284183502197334.7153205871582
14282sAMYStriatum-like amygdalar nuclei7.202717304229747.41062879562378
14282STRStriatum20.647302627563518.2398700714111
14282STRdStriatum dorsal region19.974559783935517.7059345245361
14282STRvStriatum ventral region34.143039703369127.438850402832
14282THThalamus5.770709514617925.37381267547607
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2354GO:0000074NASProcessregulation of progression through cell cycle
2354GO:0000122TASProcessnegative regulation of transcription from RNA polymerase II promoter
2354GO:0005634IEAComponentnucleus
2354GO:0006355IEAProcessregulation of transcription, DNA-dependent
2354GO:0007275TASProcessdevelopment
2354GO:0007610TASProcessbehavior
2354GO:0008134TASFunctiontranscription factor binding
2354GO:0043565IEAFunctionsequence-specific DNA binding
2354GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_006723.13726NP_002220.1jun B proto-oncogeneHPRD01270
NP_006723.13726NP_002220.1jun B proto-oncogeneHPRD01303
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2354FOSB_HUMANP53539IPR011616bZIP_1bZIP transcription factor, bZIP_1
2354FOSB_HUMANP53539IPR011700bZIP_2Basic leucine zipper
2354FOSB_HUMANP53539IPR000837Leuzip_FosFos transforming protein
2354FOSB_HUMANP53539IPR000209Pept_S8_S53Peptidase S8 and S53, subtilisin, kexin, sedolisin
2354FOSB_HUMANP53539IPR000694PRO_richProline-rich region
2354FOSB_HUMANP53539IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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