Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2355
Official Symbol:FOSL2
Other Aliases:FLJ23306|FRA2
See related:HGNC:3798|MIM:601575|HPRD:03343
Chromosome:2
Location:2p23.3
Gene Description:FOS-like antigen 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0267
ORGANISM:human
Entrez Gene ID:2355
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14284
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14284CBCerebellum4.058830738067634.88003015518188
14284CTXCerebral cortex17.344667434692414.4839220046997
14284HIPHippocampal region22.302671432495121.3625831604004
14284HPFHippocampal formation29.079269409179727.9681491851807
14284HYHypothalamus6.902016639709475.94192409515381
14284LSXLateral septal complex9.455086708068858.31229782104492
14284MBMidbrain6.120990753173835.6910228729248
14284MYMedulla8.183509826660168.92880153656006
14284OLFOlfactory bulb69.037094116210954.9456443786621
14284PPons10.027897834777811.1659078598022
14284PALPallidum7.798778057098395.3588490486145
14284RHPRetrohippocampal region42.118881225585939.033935546875
14284sAMYStriatum-like amygdalar nuclei9.32402133941657.05326557159424
14284STRStriatum12.74111843109139.04543972015381
14284STRdStriatum dorsal region7.125722408294685.07822275161743
14284STRvStriatum ventral region36.44805526733422.6215152740479
14284THThalamus4.050161361694343.25704073905945
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2355GO:0003700TASFunctiontranscription factor activity
2355GO:0005634TASComponentnucleus
2355GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
2355GO:0008219TASProcesscell death
2355GO:0043565IEAFunctionsequence-specific DNA binding
2355GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3726NP_002220.1jun B proto-oncogeneHPRD01303
NP_005244.13726-Oncogene Jun-BHPRD03343
NP_005244.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD01302
NP_005244.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD03343
NP_005244.13727NP_005345.2jun D proto-oncogeneHPRD01304
NP_005244.13727NP_005345.2jun D proto-oncogeneHPRD03343
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2355FOSL2_HUMANP15408IPR011616bZIP_1bZIP transcription factor, bZIP_1
2355FOSL2_HUMANP15408IPR011700bZIP_2Basic leucine zipper
2355FOSL2_HUMANP15408IPR000837Leuzip_FosFos transforming protein
2355FOSL2_HUMANP15408IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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