Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:242
Official Symbol:ALOX12B
Other Aliases:12R-LOX
See related:HGNC:430|MIM:603741|HPRD:04772
Chromosome:17
Location:17p13.1
Gene Description:arachidonate 12-lipoxygenase, 12R type
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0244
ORGANISM:human
Entrez Gene ID:242
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11686
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0179
ORGANISM:human
Entrez Gene ID:242
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11686CBCerebellum3.334542632102974.65059852600098
11686CTXCerebral cortex0.911575540900230.815587848424911
11686HIPHippocampal region2.974671185016633.23099726438522
11686HPFHippocampal formation2.282725036144262.22294443845749
11686HYHypothalamus0.1453246958553790.25778516754508
11686LSXLateral septal complex0.04264168813824650.0
11686MBMidbrain1.274031504988671.18118321150541
11686MYMedulla7.49056038260467.94816127419472
11686OLFOlfactory bulb0.883957445621491.22810256481171
11686PPons2.628729938529432.58640063926578
11686PALPallidum0.08700834959745410.118320640176535
11686RHPRetrohippocampal region1.162896305322650.837306931614876
11686sAMYStriatum-like amygdalar nuclei0.1611040718853470.203155413269997
11686STRStriatum0.09637815505266190.134908836334944
11686STRdStriatum dorsal region0.07820998132228850.118154149502516
11686STRvStriatum ventral region0.1428156122565270.196466833353043
11686THThalamus0.325383163988590.441386699676514
KARG Evidence 3
KARG ID:QTL0179
Trait:chronic alcohol withdrawal severity
Peak:37
Peak Marker:D11Mit4
Parents:IP2 x IR1 F2
Evidence ID:12925894
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
242GO:0004052TASFunctionarachidonate 12-lipoxygenase activity
242GO:0005506IEAFunctioniron ion binding
242GO:0006118IEAProcesselectron transport
242GO:0006629TASProcesslipid metabolism
242GO:0008544TASProcessepidermis development
242GO:0016165IEAFunctionlipoxygenase activity
242GO:0016491IEAFunctionoxidoreductase activity
242GO:0019370IEAProcessleukotriene biosynthesis
242GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3852NP_000415.1keratin 5HPRD01010
NP_001130.13852-Keratin 5HPRD04772
NP_001130.14000CAA27173.1unnamed protein productHPRD01035
NP_001130.14000CAA27173.1unnamed protein productHPRD04772
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
242LX12B_HUMANO75342IPR003006Ig_MHCImmunoglobulin/major histocompatibility complex
242LX12B_HUMANO75342IPR000907LipOaseLipoxygenase
242LX12B_HUMANO75342IPR001024LipOase_LH2Lipoxygenase, LH2
242LX12B_HUMANO75342IPR001885Mammal_lipOaseMammalian lipoxygenase

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.