Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2487
Official Symbol:FRZB
Other Aliases:FRE|FRITZ|FRP-3|FRZB-1|FRZB-PEN|FRZB1|FZRB|SFRP3|SRFP3|hFIZ
See related:HGNC:3959|MIM:605083|HPRD:07282
Chromosome:2
Location:2qter
Gene Description:frizzled-related protein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0136
ORGANISM:human
Entrez Gene ID:2487
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:20378
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20378CBCerebellum2.118833204110462.58198988437653
20378CTXCerebral cortex9.375753641128547.70895500977834
20378HIPHippocampal region16.572754224141414.2918968200684
20378HPFHippocampal formation12.11126565933239.33712339401245
20378HYHypothalamus6.935781002044687.29910826683044
20378LSXLateral septal complex0.5959239155054090.563896218935649
20378MBMidbrain0.9029877285162611.29265342156092
20378MYMedulla2.714555899302163.1073491970698
20378OLFOlfactory bulb27.638940175374325.2621806462606
20378PPons1.172514935334521.46748648087184
20378PALPallidum2.357144912083942.50211453437805
20378RHPRetrohippocampal region4.245142022768662.11382546027501
20378sAMYStriatum-like amygdalar nuclei0.9132001598676050.790638287862142
20378STRStriatum0.847211152315140.718194961547852
20378STRdStriatum dorsal region0.6072368050614990.516217790544033
20378STRvStriatum ventral region1.651408930619561.28563219805559
20378THThalamus4.31183993319674.89079643289248
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2487GO:0001501TASProcessskeletal development
2487GO:0005576ISSComponentextracellular region
2487GO:0016020TASComponentmembrane
2487GO:0016055IEAProcessWnt receptor signaling pathway
2487GO:0017147ISSFunctionWnt-protein binding
2487GO:0030154IEAProcesscell differentiation
2487GO:0030178ISSProcessnegative regulation of Wnt receptor signaling pathway
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2487SFRP3_HUMANQ92765IPR000024Fz_domainFrizzled CRD region
2487SFRP3_HUMANQ92765IPR001134Netrin_CNetrin, C-terminal

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