Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2534
Official Symbol:FYN
Other Aliases:MGC45350|SLK|SYN
See related:HGNC:4037|MIM:137025|HPRD:00655
Chromosome:6
Location:6q21
Gene Description:FYN oncogene related to SRC, FGR, YES
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0201
ORGANISM:human
Entrez Gene ID:2534
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14360
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14360CBCerebellum32.514287471771264.6440105438232
14360CTXCerebral cortex63.67319202423162.4037446975708
14360HIPHippocampal region71.785348892211988.1859397888184
14360HPFHippocampal formation67.627325057983477.0789775848389
14360HYHypothalamus48.533746957778947.9695341587067
14360LSXLateral septal complex57.759423732757657.6541433334351
14360MBMidbrain40.065490961074843.3461761474609
14360MYMedulla43.69259440898952.6060688495636
14360OLFOlfactory bulb68.753614425659271.4848442077637
14360PPons39.3871634006547.5329155921936
14360PALPallidum42.329081773757946.6231236457825
14360RHPRetrohippocampal region59.671358108520560.1497259140015
14360sAMYStriatum-like amygdalar nuclei54.712334632873554.9006657600403
14360STRStriatum48.28375482559244.4620227813721
14360STRdStriatum dorsal region44.952861309051540.4217791557312
14360STRvStriatum ventral region44.077949762344437.717200756073
14360THThalamus66.489002227783269.4335384368896
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2534GO:0000166IEAFunctionnucleotide binding
2534GO:0004713IEAFunctionprotein-tyrosine kinase activity
2534GO:0004713TASFunctionprotein-tyrosine kinase activity
2534GO:0004715NASFunctionnon-membrane spanning protein tyrosine kinase activity
2534GO:0005515IPIFunctionprotein binding
2534GO:0005524IEAFunctionATP binding
2534GO:0005524NASFunctionATP binding
2534GO:0006468IEAProcessprotein amino acid phosphorylation
2534GO:0006468NASProcessprotein amino acid phosphorylation
2534GO:0006468TASProcessprotein amino acid phosphorylation
2534GO:0006816NASProcesscalcium ion transport
2534GO:0007242IEAProcessintracellular signaling cascade
2534GO:0007243TASProcessprotein kinase cascade
2534GO:0007612TASProcesslearning
2534GO:0007631TASProcessfeeding behavior
2534GO:0008372NDComponentcellular component unknown
2534GO:0016740IEAFunctiontransferase activity
2534GO:0042802IPIFunctionidentical protein binding
2534GO:0050852IDAProcessT cell receptor signaling pathway
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5336AAH11772.1PLCG2 proteinHPRD02570
-91746AAH41119.1Splicing factor YT521-B, isoform 1HPRD11689
-5829BAA18998.1paxillin gammaHPRD03937
-51206BAB12247.1platelet glycoprotein VI-3HPRD10406
-6622NP_000336.1alpha-synuclein isoform NACP140HPRD01227
-4684NP_000606.1neural cell adhesion molecule 1 isoform 1HPRD00301
-2903NP_000824.1N-methyl-D-aspartate receptor subunit 2A precursorHPRD00698
-2904NP_000825.1N-methyl-D-aspartate receptor subunit 2B precursorHPRD00697
-3575NP_002176.1interleukin 7 receptorHPRD00893
-4099NP_002352.1myelin associated glycoprotein isoform a precursorHPRD01160
-5894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1HPRD01265
-6693NP_003114.1sialophorinHPRD06770
-6850NP_003168.2spleen tyrosine kinaseHPRD02514
-8631NP_003717.2src family associated phosphoprotein 1HPRD05396
-8651NP_003736.1suppressor of cytokine signaling 1HPRD04669
-8751NP_003806.2a disintegrin and metalloproteinase domain 15 preproproteinHPRD05674
-8936NP_003922.1Wiskott-Aldrich syndrome protein family member 1HPRD05434
-7225NP_004612.2transient receptor potential cation channel, subfamily C, member 6HPRD04710
-3717NP_004963.1Janus kinase 2HPRD00993
-5296NP_005018.1phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)HPRD04404
-2887NP_005302.2growth factor receptor-bound protein 10HPRD03312
-7409NP_005419.2vav 1 oncogeneHPRD01284
-3702NP_005537.3IL2-inducible T-cell kinaseHPRD01746
-5747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
-7277NP_005991.1tubulin, alpha 1HPRD01851
-7278NP_005992.1tubulin, alpha 2 isoform 1HPRD03958
-10376NP_006073.1tubulin, alpha, ubiquitousHPRD03960
-4915NP_006171.2neurotrophic tyrosine kinase, receptor, type 2 isoform a precursorHPRD02712
-5588NP_006248.1protein kinase C, thetaHPRD02710
-7070NP_006279.2Thy-1 cell surface antigenHPRD01769
-4739NP_006394.1neural precursor cell expressed, developmentally down-regulated 9 isoform 1HPRD11888
-10657NP_006550.1KH domain containing, RNA binding, signal transduction associated 1HPRD03926
-10666NP_006557.1CD226 antigenHPRD09252
-10163NP_008921.1WAS protein family, member 2HPRD05796
-23607NP_036252.1CD2-associated proteinHPRD05026
-27240NP_055265.1SHP2-interacting transmembrane adaptor proteinHPRD05394
-9564NP_055382.1breast cancer anti-estrogen resistance 1HPRD04248
-9672NP_055469.1syndecan 3HPRD01719
-9743NP_055530.2Rho GTPase-activating proteinHPRD12257
-23360NP_056123.1formin binding protein 4HPRD10996
-51466NP_057421.1Enah/Vasp-likeHPRD10942
-4137NP_058519.1microtubule-associated protein tau isoform 1HPRD01142
-55715NP_060580.2downstream of tyrosine kinase 4HPRD16316
-55715NP_060580.2downstream of tyrosine kinase 4BIND185533
-10603NP_066189.1adaptor protein with pleckstrin homology and src homology 2 domainsHPRD16097
-59341NP_067638.3transient receptor potential cation channel, subfamily V, member 4 isoform aHPRD05667
-79930NP_079148.1docking protein 3HPRD16834
-139716NP_542179.1Gab3 proteinHPRD06571
NP_002028.1--TCRHPRD00655
NP_002028.1--pp115HPRD00655
NP_002028.1--Reggie-1HPRD00655
NP_002028.1--Reggie-2HPRD00655
NP_002028.1--GPVIHPRD00655
NP_002028.15296-PI 3 kinase, regulatory subunit betaHPRD00655
NP_002028.17070-THY1HPRD00655
NP_002028.13575-Interleukin 7 receptorHPRD00655
NP_002028.15894-RAF1HPRD00655
NP_002028.14099-SIGLEC4AHPRD00655
NP_002028.15295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD00655
NP_002028.15336-PLC, gamma 2HPRD00655
NP_002028.17277-Tubulin alpha 1HPRD00655
NP_002028.17278-Tubulin, alpha 2HPRD00655
NP_002028.13702-ITKHPRD00655
NP_002028.110657-Sam68HPRD00655
NP_002028.14684-NCAM1HPRD00655
NP_002028.19564-p130CASHPRD00655
NP_002028.18631-SKAP55HPRD00655
NP_002028.15329-Plasminogen activator receptor, urokinase typeHPRD00655
NP_002028.16850-SYKHPRD00655
NP_002028.19672-Syndecan 3HPRD00655
NP_002028.16693-SialophorinHPRD00655
NP_002028.14915-TrkB tyrosine kinaseHPRD00655
NP_002028.17409-VAV1HPRD00655
NP_002028.18651-SOCS1HPRD00655
NP_002028.127240-SITHPRD00655
NP_002028.15781-SHP2HPRD00655
NP_002028.123607-CD2APHPRD00655
NP_002028.15588-Protein kinase C, thetaHPRD00655
NP_002028.12903-N-methyl D-aspartate receptor subunit 2AHPRD00655
NP_002028.12904-N-methyl D-aspartate receptor subunit 2BHPRD00655
NP_002028.110163-Wiskott Aldrich syndrome protein family, member 2HPRD00655
NP_002028.18936-WAVE1HPRD00655
NP_002028.13717-Janus kinase 2HPRD00655
NP_002028.110666-CD226HPRD00655
NP_002028.15829-PaxillinHPRD00655
NP_002028.12887-Grb10HPRD00655
NP_002028.16622-Synuclein alphaHPRD00655
NP_002028.15747-FAKHPRD00655
NP_002028.1139716-GRB2 associated binding protein 3HPRD00655
NP_002028.18751-ADAM15HPRD00655
NP_002028.110376-Tubulin, alpha, ubiquitousHPRD00655
NP_002028.110399-RACK1HPRD00655
NP_002028.184867-Protein tyrosine phosphatase, non receptor type 5HPRD00655
NP_002028.159341-Vanilloid receptor like channel 2HPRD00655
NP_002028.17225-TRPC6HPRD00655
NP_002028.15144AAC00042.1Human phosphodiesterase mRNA, 5' end. and translated productsBIND146009
NP_002028.17454NP_000368.1Wiskott-Aldrich syndrome proteinHPRD00655
NP_002028.17454NP_000368.1Wiskott-Aldrich syndrome proteinHPRD02314
NP_002028.15175NP_000433.2platelet/endothelial cell adhesion molecule (CD31 antigen)HPRD00655
NP_002028.17535NP_001070.2zeta-chain associated protein kinase 70kDa isoform 1HPRD00655
NP_002028.12534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
NP_002028.14068NP_002342.1SH2 domain protein 1AHPRD00655
NP_002028.14068NP_002342.1SH2 domain protein 1AHPRD02390
NP_002028.15159NP_002600.1platelet-derived growth factor receptor beta precursorHPRD00655
NP_002028.15335NP_002651.1phospholipase C, gamma 1 (formerly subtype 148)HPRD00655
NP_002028.15335NP_002651.2phospholipase C gamma 1 isoform aHPRD01398
NP_002028.15338NP_002654.2phospholipase D2HPRD00655
NP_002028.15338NP_002654.2phospholipase D2HPRD03857
NP_002028.15786NP_002827.1protein tyrosine phosphatase, receptor type, A isoform 1 precursorHPRD00655
NP_002028.15788NP_002829.2protein tyrosine phosphatase, receptor type, C isoform 1 precursorHPRD01050
NP_002028.15788NP_002829.2protein tyrosine phosphatase, receptor type, C isoform 1 precursorHPRD00655
NP_002028.17297NP_003322.2tyrosine kinase 2HPRD00655
NP_002028.18651NP_003736.1suppressor of cytokine signaling 1BIND12732
NP_002028.18935NP_003921.2src family associated phosphoprotein 2HPRD00655
NP_002028.18935NP_003921.2src family associated phosphoprotein 2HPRD05558
NP_002028.14868NP_004637.1nephrinHPRD00655
NP_002028.14868NP_004637.1nephrinHPRD04094
NP_002028.19094NP_005139.1unc119 (C.elegans) homolog isoform aHPRD00655
NP_002028.19094NP_005139.1unc119 (C.elegans) homolog isoform aHPRD04927
NP_002028.16654NP_005624.2son of sevenless homolog 1HPRD00655
NP_002028.16654NP_005624.2son of sevenless homolog 1HPRD01681
NP_002028.110188NP_005772.2activated p21cdc42Hs kinaseHPRD06104
NP_002028.110188NP_005772.2activated p21cdc42Hs kinaseHPRD00655
NP_002028.17301NP_006284.2TYRO3 protein tyrosine kinaseHPRD00655
NP_002028.17301NP_006284.2TYRO3 protein tyrosine kinaseHPRD02641
NP_002028.14162NP_006491.1melanoma cell adhesion moleculeHPRD01120
NP_002028.14162NP_006491.1melanoma cell adhesion moleculeHPRD00655
NP_002028.155824NP_060910.2phosphoprotein associated with glycosphingolipid-enriched microdomainsHPRD00655
NP_002028.155824NP_060910.2phosphoprotein associated with glycosphingolipid-enriched microdomainsHPRD05772
NP_002028.13190NP_112553.1heterogeneous nuclear ribonucleoprotein K isoform aBIND57937
NP_002028.1951475NP_751927.1NS5A proteinBIND171699
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2534IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
2534IPR000719Prot_kinaseProtein kinase
2534IPR013625PTBTensin phosphotyrosine-binding domain
2534IPR000980SH2SH2 motif
2534IPR001452SH3Src homology-3
2534IPR011511SH3_2Variant SH3
2534IPR001245Tyr_pkinaseTyrosine protein kinase
2534IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
2534IPR013695WAKWall-associated kinase
2534FYN_HUMANP06241IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
2534FYN_HUMANP06241IPR000719Prot_kinaseProtein kinase
2534FYN_HUMANP06241IPR013625PTBTensin phosphotyrosine-binding domain
2534FYN_HUMANP06241IPR000980SH2SH2 motif
2534FYN_HUMANP06241IPR001452SH3Src homology-3
2534FYN_HUMANP06241IPR011511SH3_2Variant SH3
2534FYN_HUMANP06241IPR001245Tyr_pkinaseTyrosine protein kinase
2534FYN_HUMANP06241IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
2534FYN_HUMANP06241IPR013695WAKWall-associated kinase

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