Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2548
Official Symbol:GAA
Other Aliases:LYAG
See related:HGNC:4065|MIM:606800|HPRD:06006
Chromosome:17
Location:17q25.2-q25.3
Gene Description:glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0045
ORGANISM:human
Entrez Gene ID:2548
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14387
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0185
ORGANISM:human
Entrez Gene ID:2548
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0186
ORGANISM:human
Entrez Gene ID:2548
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14387CBCerebellum67.104118347168100.0
14387CTXCerebral cortex100.0100.0
14387HIPHippocampal region100.0100.0
14387HPFHippocampal formation100.0100.0
14387HYHypothalamus100.0100.0
14387LSXLateral septal complex100.0100.0
14387MBMidbrain100.0100.0
14387MYMedulla100.0100.0
14387OLFOlfactory bulb100.0100.0
14387PPons100.0100.0
14387PALPallidum100.0100.0
14387RHPRetrohippocampal region100.0100.0
14387sAMYStriatum-like amygdalar nuclei100.0100.0
14387STRStriatum100.0100.0
14387STRdStriatum dorsal region100.0100.0
14387STRvStriatum ventral region100.0100.0
14387THThalamus100.0100.0
KARG Evidence 4
KARG ID:QTL0185
Trait:cocaine related behavior
Peak:74
Peak Marker:D11Ncvs49
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
KARG Evidence 5
KARG ID:QTL0186
Trait:differences in cocaine responsiveness
Peak:74
Peak Marker:D11JKn1
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:7932176
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2548GO:0004553IEAFunctionhydrolase activity, hydrolyzing O-glycosyl compounds
2548GO:0004558TASFunctionalpha-glucosidase activity
2548GO:0005764TASComponentlysosome
2548GO:0005975IEAProcesscarbohydrate metabolism
2548GO:0005980TASProcessglycogen catabolism
2548GO:0006091TASProcessgeneration of precursor metabolites and energy
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2548LYAG_HUMANP10253IPR000322Glyco_hydro_31Glycoside hydrolase, family 31
2548LYAG_HUMANP10253IPR000519P_trefoilP-type trefoil

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