Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2550
Official Symbol:GABBR1
Other Aliases:GABAB(1e)|GABABR1|GABBR1-3|GPRC3A|dJ271M21.1.1|dJ271M21.1.2|hGB1a
See related:HGNC:4070|MIM:603540|HPRD:04644
Chromosome:6
Location:6p21.31
Gene Description:gamma-aminobutyric acid (GABA) B receptor, 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0544
ORGANISM:human
Entrez Gene ID:2550
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81657
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0283
ORGANISM:human
Entrez Gene ID:2550
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.63
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2550GO:0004872IEAFunctionreceptor activity
2550GO:0004965IEAFunctionGABA-B receptor activity
2550GO:0004965TASFunctionGABA-B receptor activity
2550GO:0005887TASComponentintegral to plasma membrane
2550GO:0007165IEAProcesssignal transduction
2550GO:0007194TASProcessnegative regulation of adenylate cyclase activity
2550GO:0007214TASProcessgamma-aminobutyric acid signaling pathway
2550GO:0016020IEAComponentmembrane
2550GO:0016021IEAComponentintegral to membrane
2550GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9568NP_005449.5G protein-coupled receptor 51HPRD09552
-9568NP_005449.5G protein-coupled receptor 51BIND214288
-152789NP_653321.1multiple coiled-coil GABABR1-binding proteinHPRD11292
NP_001461.1--GABAR2HPRD04644
NP_001461.19568-G protein coupled receptor 51HPRD04644
NP_001461.122809-Activating transcription factor 5HPRD04644
NP_001461.1152789-Multiple coiled-coil GABABR1-binding proteinHPRD04644
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2550IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2550IPR002456GABAB1_rcptMetabotropic gamma-aminobutyric acid receptor, type B1
2550IPR002455GABAB_rcptMetabotropic gamma-aminobutyric acid receptor, type B
2550IPR000337GPCR_MgrGPCR, family 3, metabotropic glutamate receptor-like
2550IPR000436Sushi_SCR_CCPSushi/SCR/CCP
2550GABR1_HUMANQ9UBS5IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2550GABR1_HUMANQ9UBS5IPR002456GABAB1_rcptMetabotropic gamma-aminobutyric acid receptor, type B1
2550GABR1_HUMANQ9UBS5IPR002455GABAB_rcptMetabotropic gamma-aminobutyric acid receptor, type B
2550GABR1_HUMANQ9UBS5IPR000337GPCR_MgrGPCR, family 3, metabotropic glutamate receptor-like
2550GABR1_HUMANQ9UBS5IPR000436Sushi_SCR_CCPSushi/SCR/CCP

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