Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2555
Official Symbol:GABRA2
Other Aliases:-
See related:HGNC:4076|MIM:137140|HPRD:11747
Chromosome:4
Location:4p12
Gene Description:gamma-aminobutyric acid (GABA) A receptor, alpha 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14395CBCerebellum0.3119801692664620.549298152327538
14395CTXCerebral cortex1.372451066970831.1023807823658
14395HIPHippocampal region8.945543050765999.84416353702545
14395HPFHippocampal formation7.001696705818186.86971759796143
14395HYHypothalamus0.6036662161350250.478953942656517
14395LSXLateral septal complex3.337915457785132.392986593768
14395MBMidbrain1.031826660037041.38887359201908
14395MYMedulla1.842022538185121.96945582330227
14395OLFOlfactory bulb3.663712859153752.79494279623032
14395PPons0.6780079007148740.91725167632103
14395PALPallidum0.2961516585201030.260124068707228
14395RHPRetrohippocampal region3.640021800994872.70091754198074
14395sAMYStriatum-like amygdalar nuclei0.5520362704992290.4148029088974
14395STRStriatum0.7623469382524490.616762910038233
14395STRdStriatum dorsal region0.6509797722101210.610772311687469
14395STRvStriatum ventral region0.5002573169767860.291773075703532
14395THThalamus0.7330859601497650.894003137946129
KARG Evidence 1
KARG ID:HOT0165
Entrez Gene ID:2555
RefSeq ID:NM_000807
Position Information:-, ImmediateDownstream, 121bp
Linkage Marker:
Evidence Type:LINKAGE-BASED (MULTI POINTS)
Evidence Name:PUBMED
Evidence ID:15024690
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2555GO:0001505NRProcessregulation of neurotransmitter levels
2555GO:0004890IEAFunctionGABA-A receptor activity
2555GO:0005216IEAFunctionion channel activity
2555GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
2555GO:0005887TASComponentintegral to plasma membrane
2555GO:0006811IEAProcession transport
2555GO:0006821IEAProcesschloride transport
2555GO:0007214TASProcessgamma-aminobutyric acid signaling pathway
2555GO:0008503TASFunctionbenzodiazepine receptor activity
2555GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2555GBRA2_HUMANP47869IPR001390GABAAa_rcptGamma-aminobutyric-acid A receptor, alpha subunit
2555GBRA2_HUMANP47869IPR006028GABAA_rcptGamma-aminobutyric acid A receptor
2555GBRA2_HUMANP47869IPR005431GABBAa1_rcptGamma-aminobutyric-acid A receptor, alpha 1 subunit
2555GBRA2_HUMANP47869IPR005432GABBAa2_rcptGamma-aminobutyric-acid A receptor, alpha 2 subunit
2555GBRA2_HUMANP47869IPR005437GABBAg_rcptGamma-aminobutyric-acid A receptor, gamma subunit
2555GBRA2_HUMANP47869IPR006201Neur_channelNeurotransmitter-gated ion-channel
2555GBRA2_HUMANP47869IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
2555GBRA2_HUMANP47869IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region

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