Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2560
Official Symbol:GABRB1
Other Aliases:-
See related:HGNC:4081|MIM:137190|HPRD:15924
Chromosome:4
Location:4p12
Gene Description:gamma-aminobutyric acid (GABA) A receptor, beta 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0188
ORGANISM:human
Entrez Gene ID:2560
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14400
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14400CBCerebellum20.549996852874817.0522413253784
14400CTXCerebral cortex35.054976463317920.4050936698914
14400HIPHippocampal region76.847320556640654.5827236175537
14400HPFHippocampal formation71.005893707275447.6539859771729
14400HYHypothalamus32.531143188476619.070707321167
14400LSXLateral septal complex23.340922355651912.8869524002075
14400MBMidbrain15.6637973785410.5007405281067
14400MYMedulla14.698785781860410.384512424469
14400OLFOlfactory bulb59.853664398193435.4587001800537
14400PPons15.871253013610810.7869720458984
14400PALPallidum18.792735099792511.9985284805298
14400RHPRetrohippocampal region61.710161209106438.0698680877686
14400sAMYStriatum-like amygdalar nuclei62.9367465972934.7399005889893
14400STRStriatum14.78395223617558.25684404373169
14400STRdStriatum dorsal region4.381608366966252.81756687164307
14400STRvStriatum ventral region17.84816694259648.28850114345551
14400THThalamus20.91353797912612.1401386260986
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2560GO:0004890TASFunctionGABA-A receptor activity
2560GO:0005216IEAFunctionion channel activity
2560GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
2560GO:0005887TASComponentintegral to plasma membrane
2560GO:0006811IEAProcession transport
2560GO:0007165TASProcesssignal transduction
2560GO:0030594IEAFunctionneurotransmitter receptor activity
2560GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000803.15290-Phosphatidylinositol 3 kinase, catalytic subunit alphaHPRD15924
NP_000803.19495NP_004848.2A-kinase anchor protein 5HPRD15924
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2560GBRB1_HUMANP18505IPR001390GABAAa_rcptGamma-aminobutyric-acid A receptor, alpha subunit
2560GBRB1_HUMANP18505IPR002289GABAAb_rcptGamma-aminobutyric-acid A receptor, beta subunit
2560GBRB1_HUMANP18505IPR006028GABAA_rcptGamma-aminobutyric acid A receptor
2560GBRB1_HUMANP18505IPR005437GABBAg_rcptGamma-aminobutyric-acid A receptor, gamma subunit
2560GBRB1_HUMANP18505IPR006201Neur_channelNeurotransmitter-gated ion-channel
2560GBRB1_HUMANP18505IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
2560GBRB1_HUMANP18505IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.