Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2561
Official Symbol:GABRB2
Other Aliases:MGC119386|MGC119388|MGC119389
See related:HGNC:4082|MIM:600232|HPRD:02578
Chromosome:5
Location:5q34
Gene Description:gamma-aminobutyric acid (GABA) A receptor, beta 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0942
ORGANISM:human
Entrez Gene ID:2561
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14401CBCerebellum35.799933433532764.2528800964355
14401CTXCerebral cortex64.819259643554759.5745906829834
14401HIPHippocampal region58.886077880859459.5895309448242
14401HPFHippocampal formation63.109533309936561.3223266601562
14401HYHypothalamus26.447371482849128.1101293563843
14401LSXLateral septal complex10.57905864715588.60920560359955
14401MBMidbrain50.188528060913161.7183017730713
14401MYMedulla9.7748253345489512.9439587593079
14401OLFOlfactory bulb60.070007324218874.0696125030518
14401PPons16.620881557464623.5690860748291
14401PALPallidum45.052484512329178.2886543273926
14401RHPRetrohippocampal region71.418338775634863.5027885437012
14401sAMYStriatum-like amygdalar nuclei35.560020446777341.5632276535034
14401STRStriatum10.171457290649410.7190585136414
14401STRdStriatum dorsal region4.780379652976994.58458602428436
14401STRvStriatum ventral region16.386372566223117.0207161903381
14401THThalamus52.97134208679266.897346496582
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2561GO:0004890TASFunctionGABA-A receptor activity
2561GO:0005216IEAFunctionion channel activity
2561GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
2561GO:0005887TASComponentintegral to plasma membrane
2561GO:0006811IEAProcession transport
2561GO:0007214TASProcessgamma-aminobutyric acid signaling pathway
2561GO:0007268TASProcesssynaptic transmission
2561GO:0030594IEAFunctionneurotransmitter receptor activity
2561GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3350NP_000515.15-hydroxytryptamine (serotonin) receptor 1AHPRD00190
NP_068711.13350-5-hydroxytryptamine receptor, 1AHPRD02578
NP_068711.166008NP_055864.1trafficking protein, kinesin binding 2HPRD02578
NP_068711.166008NP_055864.1trafficking protein, kinesin binding 2HPRD09547
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2561IPR001390GABAAa_rcptGamma-aminobutyric-acid A receptor, alpha subunit
2561IPR002289GABAAb_rcptGamma-aminobutyric-acid A receptor, beta subunit
2561IPR006028GABAA_rcptGamma-aminobutyric acid A receptor
2561IPR005437GABBAg_rcptGamma-aminobutyric-acid A receptor, gamma subunit
2561IPR006201Neur_channelNeurotransmitter-gated ion-channel
2561IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
2561IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
2561GBRB2_HUMANP47870IPR001390GABAAa_rcptGamma-aminobutyric-acid A receptor, alpha subunit
2561GBRB2_HUMANP47870IPR002289GABAAb_rcptGamma-aminobutyric-acid A receptor, beta subunit
2561GBRB2_HUMANP47870IPR006028GABAA_rcptGamma-aminobutyric acid A receptor
2561GBRB2_HUMANP47870IPR005437GABBAg_rcptGamma-aminobutyric-acid A receptor, gamma subunit
2561GBRB2_HUMANP47870IPR006201Neur_channelNeurotransmitter-gated ion-channel
2561GBRB2_HUMANP47870IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
2561GBRB2_HUMANP47870IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region

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