Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2566
Official Symbol:GABRG2
Other Aliases:CAE2|ECA2|GEFSP3
See related:HGNC:4087|MIM:137164|HPRD:00663
Chromosome:5
Location:5q31.1-q33.1
Gene Description:gamma-aminobutyric acid (GABA) A receptor, gamma 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0353
ORGANISM:human
Entrez Gene ID:2566
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14406
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0178
ORGANISM:human
Entrez Gene ID:2566
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14406CBCerebellum65.710854530334582.8921394348145
14406CTXCerebral cortex92.158477783203188.1761856079102
14406HIPHippocampal region80.181741714477588.463996887207
14406HPFHippocampal formation82.968555450439585.7754402160645
14406HYHypothalamus85.846179962158285.7491912841797
14406LSXLateral septal complex57.10136651992854.4071412086487
14406MBMidbrain81.679758071899484.9151611328125
14406MYMedulla65.588315963745168.6644897460938
14406OLFOlfactory bulb95.753738403320398.9628257751465
14406PPons71.469995498657274.9161167144775
14406PALPallidum75.771381378173886.9194755554199
14406RHPRetrohippocampal region86.605064392089882.0710296630859
14406sAMYStriatum-like amygdalar nuclei74.419675827026475.4101810455322
14406STRStriatum57.47824144363453.9954285621643
14406STRdStriatum dorsal region53.395077466964743.2687323093414
14406STRvStriatum ventral region63.526361465454160.7502298355103
14406THThalamus57.293506145477356.4028086662292
KARG Evidence 3
KARG ID:QTL0178
Trait:high-dose ethanol actions
Peak:19
Peak Marker:GABRA1
Parents:LS x SS intercross
Evidence ID:9023306
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2566GO:0004890IEAFunctionGABA-A receptor activity
2566GO:0005216IEAFunctionion channel activity
2566GO:0005230IEAFunctionextracellular ligand-gated ion channel activity
2566GO:0005515IPIFunctionprotein binding
2566GO:0005887TASComponentintegral to plasma membrane
2566GO:0006811IEAProcession transport
2566GO:0006821IEAProcesschloride transport
2566GO:0007214IEAProcessgamma-aminobutyric acid signaling pathway
2566GO:0007214TASProcessgamma-aminobutyric acid signaling pathway
2566GO:0008503TASFunctionbenzodiazepine receptor activity
2566GO:0016021IEAComponentintegral to membrane
2566GO:0030594IEAFunctionneurotransmitter receptor activity
2566GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000807.1--GABARAPHPRD00663
NP_000807.111337NP_009209.1GABA(A) receptor-associated proteinHPRD00663
NP_000807.111337NP_009209.1GABA(A) receptor-associated proteinHPRD05496
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2566IPR001390GABAAa_rcptGamma-aminobutyric-acid A receptor, alpha subunit
2566IPR006028GABAA_rcptGamma-aminobutyric acid A receptor
2566IPR005439GABBAg2_rcptGamma-aminobutyric-acid A receptor, gamma 2 subunit
2566IPR005437GABBAg_rcptGamma-aminobutyric-acid A receptor, gamma subunit
2566IPR006201Neur_channelNeurotransmitter-gated ion-channel
2566IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
2566IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region
2566GBRG2_HUMANP18507IPR001390GABAAa_rcptGamma-aminobutyric-acid A receptor, alpha subunit
2566GBRG2_HUMANP18507IPR006028GABAA_rcptGamma-aminobutyric acid A receptor
2566GBRG2_HUMANP18507IPR005439GABBAg2_rcptGamma-aminobutyric-acid A receptor, gamma 2 subunit
2566GBRG2_HUMANP18507IPR005437GABBAg_rcptGamma-aminobutyric-acid A receptor, gamma subunit
2566GBRG2_HUMANP18507IPR006201Neur_channelNeurotransmitter-gated ion-channel
2566GBRG2_HUMANP18507IPR006202Neur_chan_lig_bdNeurotransmitter-gated ion-channel ligand-binding
2566GBRG2_HUMANP18507IPR006029Neu_channel_TMNeurotransmitter-gated ion-channel transmembrane region

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