Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2571
Official Symbol:GAD1
Other Aliases:GAD
See related:HGNC:4092|MIM:605363|HPRD:12011
Chromosome:2
Location:2q31
Gene Description:glutamate decarboxylase 1 (brain, 67kDa)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0571
ORGANISM:human
Entrez Gene ID:2571
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24379
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0126
ORGANISM:human
Entrez Gene ID:2571
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:0.40 :: 1.07 :: 2.04 :: 1.53 :: -1.99 :: -1.44 :: -1.34
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14415CBCerebellum95.28258150248395.3097816081274
14415CTXCerebral cortex77.208918526059195.0416661217099
14415HIPHippocampal region81.019468077591595.2636442894027
14415HPFHippocampal formation82.251375862530395.2615504633813
14415HYHypothalamus95.279431467964595.4215798605056
14415LSXLateral septal complex95.240216305390795.2380952380952
14415MBMidbrain93.102628906567995.3403103578658
14415MYMedulla87.890330404043295.2553168237209
14415OLFOlfactory bulb95.284214209942695.2732497936203
14415PPons72.523615520624995.2341435182662
14415PALPallidum95.257863893395495.2572241581622
14415RHPRetrohippocampal region83.494324025653795.2574137733096
14415sAMYStriatum-like amygdalar nuclei95.264238525004695.2741153183437
14415STRStriatum95.254117454801395.2558455836205
14415STRdStriatum dorsal region95.256157047691895.2594260942368
14415STRvStriatum ventral region95.248854813121695.2444572122324
14415THThalamus31.350578327973765.2797530236698
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2571GO:0004351IDAFunctionglutamate decarboxylase activity
2571GO:0005515IPIFunctionprotein binding
2571GO:0005622IDAComponentintracellular
2571GO:0006540TASProcessglutamate decarboxylation to succinate
2571GO:0007268TASProcesssynaptic transmission
2571GO:0012506NASComponentvesicle membrane
2571GO:0016829IEAFunctionlyase activity
2571GO:0018352TASProcessprotein-pyridoxal-5-phosphate linkage
2571GO:0019752IEAProcesscarboxylic acid metabolism
2571GO:0042136IEAProcessneurotransmitter biosynthesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2572NP_000809.1glutamate decarboxylase 2HPRD11817
NP_000808.12572-Glutamate decarboxylase 2HPRD12011
NT_005403.15---BIND185489
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2571IPR002129Pyridoxal_deCPyridoxal-dependent decarboxylase
2571DCE1_HUMANQ99259IPR010977Aromatic_deCAromatic-L-amino-acid decarboxylase
2571DCE1_HUMANQ99259IPR002129Pyridoxal_deCPyridoxal-dependent decarboxylase

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