Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2581
Official Symbol:GALC
Other Aliases:-
See related:HGNC:4115|MIM:606890|HPRD:06057
Chromosome:14
Location:14q31
Gene Description:galactosylceramidase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0834
ORGANISM:human
Entrez Gene ID:2581
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: -1.2 :: 1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14420CBCerebellum3.573368072509774.00019121170044
14420CTXCerebral cortex4.038928508758543.01108622550964
14420HIPHippocampal region7.016467571258546.30406665802002
14420HPFHippocampal formation6.604574203491215.53206396102905
14420HYHypothalamus1.481952071189881.18132972717285
14420LSXLateral septal complex2.237484455108641.57832181453705
14420MBMidbrain1.507085204124451.77427852153778
14420MYMedulla2.881787776947023.62695407867432
14420OLFOlfactory bulb7.602859020233156.26416635513306
14420PPons2.309079647064212.9104425907135
14420PALPallidum1.593709468841551.20478451251984
14420RHPRetrohippocampal region5.931566715240484.50194787979126
14420sAMYStriatum-like amygdalar nuclei4.116349220275882.74237203598022
14420STRStriatum1.447396636009221.0965803861618
14420STRdStriatum dorsal region0.7312704324722290.637775480747223
14420STRvStriatum ventral region2.245024204254151.61150324344635
14420THThalamus1.113539338111880.946025848388672
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2581GO:0004336IEAFunctiongalactosylceramidase activity
2581GO:0005764TASComponentlysosome
2581GO:0005975IEAProcesscarbohydrate metabolism
2581GO:0006683IEAProcessgalactosylceramide catabolism
2581GO:0016798IEAFunctionhydrolase activity, acting on glycosyl bonds
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2581GALC_HUMANP54803IPR001286Glyco_hydro_59Glycoside hydrolase, family 59

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