Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:25939
Official Symbol:SAMHD1
Other Aliases:DCIP|HDDC1|MOP-5|SBBI88
See related:HGNC:15925|MIM:606754|HPRD:08418
Chromosome:20
Location:20pter-q12
Gene Description:SAM domain and HD domain 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0278
ORGANISM:human
Entrez Gene ID:25939
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.79
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
56045CBCerebellum2.045573472976682.08421587944031
56045CTXCerebral cortex1.380831241607670.886949002742767
56045HIPHippocampal region2.508070230484012.15433740615845
56045HPFHippocampal formation2.091335535049441.68413865566254
56045HYHypothalamus2.297902584075930.980164527893066
56045LSXLateral septal complex7.030777931213384.15870237350464
56045MBMidbrain1.754687666893011.14914441108704
56045MYMedulla7.121428489685063.38330030441284
56045OLFOlfactory bulb4.708081245422362.36689639091492
56045PPons5.218459606170652.94005846977234
56045PALPallidum1.850196838378910.986316680908203
56045RHPRetrohippocampal region1.288350224494930.968291521072388
56045sAMYStriatum-like amygdalar nuclei1.690710902214050.603338062763214
56045STRStriatum1.576473116874690.769162833690643
56045STRdStriatum dorsal region0.8180838227272030.397930055856705
56045STRvStriatum ventral region1.97861254215240.783157646656036
56045THThalamus1.275439262390140.941346347332001
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
25939GO:0003824IEAFunctioncatalytic activity
25939GO:0004114IEAFunction3',5'-cyclic-nucleotide phosphodiesterase activity
25939GO:0005622NASComponentintracellular
25939GO:0006955NASProcessimmune response
25939GO:0007165IEAProcesssignal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
25939SAMH1_HUMANQ9Y3Z3IPR006674HD_hydroMetal-dependent phosphohydrolase, HD subdomain
25939SAMH1_HUMANQ9Y3Z3IPR001660SAMSterile alpha motif SAM
25939SAMH1_HUMANQ9Y3Z3IPR011510SAM_2Sterile alpha motif homology 2

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