Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2596
Official Symbol:GAP43
Other Aliases:B-50|PP46
See related:HGNC:4140|MIM:162060|HPRD:01198
Chromosome:3
Location:3q13.1-q13.2
Gene Description:growth associated protein 43
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0109
ORGANISM:human
Entrez Gene ID:2596
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:3.32 :: 4.06 :: 1.33 :: 0.74 :: -2.52 :: -4.85 :: -2.91
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14432CBCerebellum100.0100.0
14432CTXCerebral cortex100.0100.0
14432HIPHippocampal region80.547830581665100.0
14432HPFHippocampal formation100.0100.0
14432HYHypothalamus100.0100.0
14432LSXLateral septal complex100.0100.0
14432MBMidbrain100.0100.0
14432MYMedulla99.102840423584100.0
14432OLFOlfactory bulb100.0100.0
14432PPons100.0100.0
14432PALPallidum100.0100.0
14432RHPRetrohippocampal region100.0100.0
14432sAMYStriatum-like amygdalar nuclei100.0100.0
14432STRStriatum100.0100.0
14432STRdStriatum dorsal region100.0100.0
14432STRvStriatum ventral region100.0100.0
14432THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2596GO:0001558IEAProcessregulation of cell growth
2596GO:0005516IEAFunctioncalmodulin binding
2596GO:0007205TASProcessprotein kinase C activation
2596GO:0007399IEAProcessnervous system development
2596GO:0009611TASProcessresponse to wounding
2596GO:0016020IEAComponentmembrane
2596GO:0030154IEAProcesscell differentiation
2596GO:0040008IEAProcessregulation of growth
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6709NP_003118.1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD01684
-9135NP_004694.2rabaptin, RAB GTPase binding effector protein 1HPRD04684
NP_002036.1--CalmodulinHPRD01198
NP_002036.1--PLC- deltaHPRD01198
NP_002036.19135-Rabaptin 5HPRD01198
NP_002036.16709-SpectrinHPRD01198
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2596NEUM_HUMANP17677IPR000048IQ_CaM_bd_regionIQ calmodulin-binding region
2596NEUM_HUMANP17677IPR001422NeuromodulinNeuromodulin (GAP-43)

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