Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2597
Official Symbol:GAPDH
Other Aliases:G3PD|GAPD|MGC88685
See related:HGNC:4141|MIM:138400|HPRD:00713
Chromosome:12
Location:12p13
Gene Description:glyceraldehyde-3-phosphate dehydrogenase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0412
ORGANISM:human
Entrez Gene ID:2597
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24383
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0955
ORGANISM:human
Entrez Gene ID:2597
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.9 :: -1.6
KARG Evidence 3
KARG ID:EVIP0259
ORGANISM:human
Entrez Gene ID:2597
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:16172612
Addiction Drug:ALCOHOL
Addiction Drug Detail:Chronic alcohol use
Addiction Brain Area:Brain
Drug Effects:Downregulated
Fold Change:-1.1::-1.5;1.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2597GO:0004365NASFunctionglyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
2597GO:0005737NASComponentcytoplasm
2597GO:0006006IEAProcessglucose metabolism
2597GO:0006096NASProcessglycolysis
2597GO:0016491IEAFunctionoxidoreductase activity
2597GO:0051287IEAFunctionNAD binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6277AAH09017.1S100A6 proteinHPRD00237
-6310NP_000323.1ataxin 1HPRD03333
-2911NP_000829.1glutamate receptor, metabotropic 1HPRD05129
-5338NP_002654.2phospholipase D2HPRD03857
-5584NP_002731.3protein kinase C, iotaHPRD02105
-8655NP_003737.1dynein light chain 1HPRD03334
-64714NP_006840.1protein disulfide isomerase-associated 2HPRD07617
NP_002037.2--ActinHPRD00713
NP_002037.2--TubulinHPRD00713
NP_002037.26277-CalcyclinHPRD00713
NP_002037.26310-Ataxin 1HPRD00713
NP_002037.22911-Metabotropic glutamate receptor 1HPRD00713
NP_002037.264714-Protein disulfide isomerase A2HPRD00713
NP_002037.25584-Protein kinase C, iota typeHPRD00713
NP_002037.25338-Phospholipase D2HPRD00713
NP_002037.28655-DLC1HPRD00713
NP_002037.25230NP_000282.1phosphoglycerate kinase 1HPRD02412
NP_002037.25230NP_000282.1phosphoglycerate kinase 1HPRD00713
NP_002037.22597NP_002037.2glyceraldehyde-3-phosphate dehydrogenaseHPRD00713
NP_002037.23064NP_002102.2huntingtinHPRD00883
NP_002037.23064NP_002102.2huntingtinHPRD00713
NP_002037.210492NP_006363.3synaptotagmin binding, cytoplasmic RNA interacting proteinBIND182484
NP_002037.26513NP_006507.1solute carrier family 2 (facilitated glucose transporter), member 1HPRD00713
NP_002037.26513NP_006507.1solute carrier family 2 (facilitated glucose transporter), member 1HPRD00683
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2597G3P_HUMANP04406IPR000173GAP_DHGlyceraldehyde 3-phosphate dehydrogenase

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