Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2617
Official Symbol:GARS
Other Aliases:CMT2D|DSMAV|GlyRS|SMAD1
See related:HGNC:4162|MIM:600287
Chromosome:7
Location:7p15
Gene Description:glycyl-tRNA synthetase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0375
ORGANISM:human
Entrez Gene ID:2617
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:297113
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0973
ORGANISM:human
Entrez Gene ID:2617
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -2.1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
353172CBCerebellum100.0100.0
353172CTXCerebral cortex100.0100.0
353172HIPHippocampal region100.0100.0
353172HPFHippocampal formation100.0100.0
353172HYHypothalamus100.0100.0
353172LSXLateral septal complex100.0100.0
353172MBMidbrain100.0100.0
353172MYMedulla100.0100.0
353172OLFOlfactory bulb100.0100.0
353172PPons100.0100.0
353172PALPallidum100.0100.0
353172RHPRetrohippocampal region100.0100.0
353172sAMYStriatum-like amygdalar nuclei100.0100.0
353172STRStriatum100.0100.0
353172STRdStriatum dorsal region100.0100.0
353172STRvStriatum ventral region100.0100.0
353172THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2617GO:0000166IEAFunctionnucleotide binding
2617GO:0004820TASFunctionglycine-tRNA ligase activity
2617GO:0005524IEAFunctionATP binding
2617GO:0005625TASComponentsoluble fraction
2617GO:0005737TASComponentcytoplasm
2617GO:0006412IEAProcessprotein biosynthesis
2617GO:0006426IEAProcessglycyl-tRNA aminoacylation
2617GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
AAH00065.13376NP_038203.1isoleucine-tRNA synthetaseHPRD02832
AAH00065.13376NP_038203.1isoleucine-tRNA synthetaseHPRD02617
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2617SYG_HUMANP41250IPR004154Anticodon_bdAnticodon-binding
2617SYG_HUMANP41250IPR002314tRNA-synt_2btRNA synthetase, class II (G, H, P and S)
2617SYG_HUMANP41250IPR002315tRNA-synt_glyGlycyl-tRNA synthetase, alpha2 dimer
2617SYG_HUMANP41250IPR002316tRNA-synt_proProlyl-tRNA synthetase, class IIa
2617SYG_HUMANP41250IPR006195tRNA_ligase_IIAminoacyl-transfer RNA synthetase, class II
2617SYG_HUMANP41250IPR000738WHEP-TRSWHEP-TRS

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