Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2643
Official Symbol:GCH1
Other Aliases:DYT5|GCH|GTP-CH-1|GTPCH1
See related:HGNC:4193|MIM:600225|HPRD:02573
Chromosome:14
Location:14q22.1-q22.2
Gene Description:GTP cyclohydrolase 1 (dopa-responsive dystonia)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0208
ORGANISM:human
Entrez Gene ID:2643
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14528CBCerebellum0.8608988672494891.57482019066811
14528CTXCerebral cortex0.266537651419640.414562672376633
14528HIPHippocampal region0.2669845446944240.383100792765617
14528HPFHippocampal formation0.3320254907011990.442973881959915
14528HYHypothalamus0.5649580210447310.948061883449554
14528LSXLateral septal complex0.09640901535749440.379507035017014
14528MBMidbrain3.848368406295787.00555396080017
14528MYMedulla1.528277277946472.48926949501038
14528OLFOlfactory bulb1.04710036516192.41087394952774
14528PPons2.629304289817814.80589377880096
14528PALPallidum0.2209502905607220.409604050219059
14528RHPRetrohippocampal region0.381689772009850.427611887454987
14528sAMYStriatum-like amygdalar nuclei0.3543394356966020.970472849905491
14528STRStriatum0.1759817823767660.321340627968311
14528STRdStriatum dorsal region0.1332422792911530.16087756305933
14528STRvStriatum ventral region0.2746156640350820.476175390183926
14528THThalamus0.3443717435002330.649117946624756
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2643GO:0003934TASFunctionGTP cyclohydrolase I activity
2643GO:0006559IEAProcessL-phenylalanine catabolism
2643GO:0006729IEAProcesstetrahydrobiopterin biosynthesis
2643GO:0006809TASProcessnitric oxide biosynthesis
2643GO:0016787IEAFunctionhydrolase activity
2643GO:0042133TASProcessneurotransmitter metabolism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2644NP_005249.1GTP cyclohydrolase I feedback regulatory proteinHPRD03895
-22895NP_055769.2rabphilin 3A homologHPRD15273
NP_000152.12644-GFRPHPRD02573
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2643GCH1_HUMANP30793IPR001474GTP_cyclohydroIGTP cyclohydrolase I

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