Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2668
Official Symbol:GDNF
Other Aliases:ATF1|ATF2|HFB1-GDNF
See related:HGNC:4232|MIM:600837|HPRD:02906
Chromosome:5
Location:5p13.1-p12
Gene Description:glial cell derived neurotrophic factor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0099
ORGANISM:human
Entrez Gene ID:2668
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14573
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0513
ORGANISM:human
Entrez Gene ID:2668
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25453
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVID0018
ORGANISM:human
Entrez Gene ID:2668
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:600837
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14573CBCerebellum42.692012786865263.4999961853027
14573CTXCerebral cortex35.32457733154324.9070434570312
14573HIPHippocampal region28.805482864379932.7953491210938
14573HPFHippocampal formation30.344083786010729.2370262145996
14573HYHypothalamus6.807592868804935.95212459564209
14573LSXLateral septal complex2.071319341659551.51407432556152
14573MBMidbrain8.47856235504157.62757873535156
14573MYMedulla10.633231163024910.4370241165161
14573OLFOlfactory bulb36.656009674072330.3498096466064
14573PPons9.119609832763679.35526847839355
14573PALPallidum12.153258323669410.7105102539062
14573RHPRetrohippocampal region32.72644805908225.0261478424072
14573sAMYStriatum-like amygdalar nuclei12.863190650939910.3241052627563
14573STRStriatum29.849565505981423.1457710266113
14573STRdStriatum dorsal region32.816753387451225.0395240783691
14573STRvStriatum ventral region36.563480377197328.7699279785156
14573THThalamus20.466697692871118.6350612640381
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2668GO:0000004NDProcessbiological process unknown
2668GO:0006916TASProcessanti-apoptosis
2668GO:0007165TASProcesssignal transduction
2668GO:0007399TASProcessnervous system development
2668GO:0008083IEAFunctiongrowth factor activity
2668GO:0008083NASFunctiongrowth factor activity
2668GO:0008372NDComponentcellular component unknown
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2675NP_001486.4GDNF family receptor alpha 2 preproproteinHPRD11801
NP_000505.1--GFR alpha2HPRD02906
NP_000505.12674NP_005255.1GDNF family receptor alpha 1 isoform a preproproteinHPRD03291
NP_000505.12674NP_005255.1GDNF family receptor alpha 1 isoform a preproproteinHPRD02906
NP_000505.15979NP_066124.1ret proto-oncogene isoform aHPRD02906
NP_000505.15979NP_066124.1ret proto-oncogene isoform aHPRD01266
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2668IPR001839TGFbTransforming growth factor beta
2668GDNF_HUMANP39905IPR001839TGFbTransforming growth factor beta

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