Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2669
Official Symbol:GEM
Other Aliases:KIR|MGC26294
See related:HGNC:4234|MIM:600164
Chromosome:8
Location:8q13-q21
Gene Description:GTP binding protein overexpressed in skeletal muscle
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0054
ORGANISM:human
Entrez Gene ID:2669
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:1.58 :: 0.41 :: -0.47 :: -0.24 :: -0.25 :: 0.20 :: 0.79 :: 0.74 :: 0.43 :: 0.71
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14579CBCerebellum3.105840563774113.94404828548431
14579CTXCerebral cortex2.898438096046453.3034862279892
14579HIPHippocampal region2.540320098400122.9607241153717
14579HPFHippocampal formation1.948676466941832.06905180215836
14579HYHypothalamus3.468318223953252.94852578639984
14579LSXLateral septal complex1.512869417667391.35851693153381
14579MBMidbrain2.384543657302863.05003190040588
14579MYMedulla8.6954054832458512.9220929145813
14579OLFOlfactory bulb5.463697671890264.44158756732941
14579PPons6.262469768524179.57358551025391
14579PALPallidum1.980017244815831.77890461683273
14579RHPRetrohippocampal region1.245668858289721.12527260184288
14579sAMYStriatum-like amygdalar nuclei2.258183538913732.00215071439743
14579STRStriatum1.378366768360141.24290886521339
14579STRdStriatum dorsal region1.063074320554731.05267456173897
14579STRvStriatum ventral region1.924339950084691.4012094438076
14579THThalamus2.920831441879272.73271870613098
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2669GO:0000166IEAFunctionnucleotide binding
2669GO:0005516IEAFunctioncalmodulin binding
2669GO:0005525TASFunctionGTP binding
2669GO:0006955TASProcessimmune response
2669GO:0007166TASProcesscell surface receptor linked signal transduction
2669GO:0007264IEAProcesssmall GTPase mediated signal transduction
2669GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_005252.151291NP_057657.1GEM interacting proteinHPRD11553
NP_005252.151291NP_057657.1GEM interacting proteinHPRD11005
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2669GEM_HUMANP55040IPR013684Miro-likeMiro-like
2669GEM_HUMANP55040IPR013753RasRas
2669GEM_HUMANP55040IPR001806Ras_trnsfrmngRas GTPase

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