Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2670
Official Symbol:GFAP
Other Aliases:FLJ45472
See related:HGNC:4235|MIM:137780|HPRD:00675
Chromosome:17
Location:17q21
Gene Description:glial fibrillary acidic protein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0135
ORGANISM:human
Entrez Gene ID:2670
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14580
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0162
ORGANISM:human
Entrez Gene ID:2670
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:superior frontal gyrus
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 3
KARG ID:EVIM0167
ORGANISM:human
Entrez Gene ID:2670
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 4
KARG ID:EVIM0176
ORGANISM:human
Entrez Gene ID:2670
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 5
KARG ID:EVIM0360
ORGANISM:human
Entrez Gene ID:2670
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: -2.2 :: 1 :: -1.5 :: -1.3 :: -2.1
KARG Evidence 6
KARG ID:EVIM0428
ORGANISM:human
Entrez Gene ID:2670
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.3 :: 1.8 :: -1.1 :: 2.1
KARG Evidence 7
KARG ID:EVIM0839
ORGANISM:human
Entrez Gene ID:2670
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-3.1 :: -2.2 :: -1.9 :: -2.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14580CBCerebellum52.781703948974652.5495853424072
14580CTXCerebral cortex13.540063858032211.8580384254456
14580HIPHippocampal region60.059888839721759.3677864074707
14580HPFHippocampal formation49.380142211914146.2028427124023
14580HYHypothalamus19.953452110290518.6529550552368
14580LSXLateral septal complex35.842377662658731.1514654159546
14580MBMidbrain29.51519393920936.8639221191406
14580MYMedulla77.00860214233478.4706497192383
14580OLFOlfactory bulb56.633096694946338.3426780700684
14580PPons67.868041992187575.0634078979492
14580PALPallidum23.944693565368720.8293476104736
14580RHPRetrohippocampal region30.828362464904826.8438014984131
14580sAMYStriatum-like amygdalar nuclei23.711812973022521.5275421142578
14580STRStriatum18.711318016052217.6160802841187
14580STRdStriatum dorsal region17.813769817352318.5630221366882
14580STRvStriatum ventral region10.71814298629766.07104086875916
14580THThalamus34.507093429565438.385217666626
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2670GO:0005200TASFunctionstructural constituent of cytoskeleton
2670GO:0005882TASComponentintermediate filament
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4221NP_000235.2menin isoform 1HPRD00564
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
NP_002046.16271-S100 alphaHPRD00675
NP_002046.16285-S100 calcium binding protein, betaHPRD00675
NP_002046.16714-c-SrcHPRD00675
NP_002046.15663-Presenilin 1HPRD00675
NP_002046.14221-MeninHPRD00675
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2670GFAP_HUMANP14136IPR006821filament_DNA_bdIntermediate filament, DNA-binding region
2670GFAP_HUMANP14136IPR001664IFIntermediate filament protein
2670GFAP_HUMANP14136IPR002957Keratin_IKeratin, type I

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