Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2697
Official Symbol:GJA1
Other Aliases:CX43|DFNB38|GJAL|ODD|ODDD|ODOD|SDTY3
See related:HGNC:4274|MIM:121014|HPRD:00414
Chromosome:6
Location:6q21-q23.2
Gene Description:gap junction protein, alpha 1, 43kDa (connexin 43)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0945
ORGANISM:human
Entrez Gene ID:2697
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1 :: -2.1 :: -1.4 :: -1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14609CBCerebellum88.9890543619792100.0
14609CTXCerebral cortex60.048519134521555.2026507059733
14609HIPHippocampal region85.693756103515691.4856694539388
14609HPFHippocampal formation84.800148010253986.3322575887044
14609HYHypothalamus85.549769083658981.2790781656901
14609LSXLateral septal complex100.099.0905329386393
14609MBMidbrain86.032414754231880.8087819417318
14609MYMedulla84.515706380208381.2300211588542
14609OLFOlfactory bulb82.284606933593875.8792661031087
14609PPons77.850072224934975.8075701395671
14609PALPallidum82.249722798665477.3642743428548
14609RHPRetrohippocampal region83.205485026041778.9677670796712
14609sAMYStriatum-like amygdalar nuclei81.716079711914181.7116877237956
14609STRStriatum72.098522186279368.0281016031901
14609STRdStriatum dorsal region63.956746419270860.8959566752116
14609STRvStriatum ventral region70.27569198608462.4198137919108
14609THThalamus79.305018107096473.4718742370605
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2697GO:0004871IMPFunctionsignal transducer activity
2697GO:0005515ISSFunctionprotein binding
2697GO:0005887TASComponentintegral to plasma membrane
2697GO:0005922TASComponentconnexon complex
2697GO:0006810TASProcesstransport
2697GO:0006936TASProcessmuscle contraction
2697GO:0007267TASProcesscell-cell signaling
2697GO:0007507TASProcessheart development
2697GO:0007605IEAProcesssensory perception of sound
2697GO:0015075TASFunctionion transporter activity
2697GO:0015285TASFunctionconnexon channel activity
2697GO:0016020IEAComponentmembrane
2697GO:0016264TASProcessgap junction assembly
2697GO:0043123IMPProcesspositive regulation of I-kappaB kinase/NF-kappaB cascade
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7082NP_003248.2tight junction protein 1 isoform aHPRD03002
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-2700NP_068773.2gap junction protein, alpha 3, 46kDa (connexin 46)HPRD00415
-5598NP_620603.1mitogen-activated protein kinase 7 isoform 1HPRD03952
NP_000156.16714-c-SrcHPRD00414
NP_000156.17082-Tight junction protein 1HPRD00414
NP_000156.15581-Protein kinase C epsilonHPRD00414
NP_000156.15578-Protein kinase C alphaHPRD00414
NP_000156.12700-Connexin 46HPRD00414
NP_000156.15598-ERK5HPRD00414
NP_000156.12702NP_005257.2gap junction protein, alpha 5HPRD08699
NP_000156.12702NP_005257.2gap junction protein, alpha 5HPRD00414
NP_000156.16714NP_005408.1proto-oncogene tyrosine-protein kinase SRCBIND196377
NP_000156.16271NP_006262.1S100 calcium binding protein A1HPRD00414
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2697CXA1_HUMANP17302IPR000500ConnexinConnexins
2697CXA1_HUMANP17302IPR002261Connexin43Gap junction alpha-1 protein (Cx43)
2697CXA1_HUMANP17302IPR013124Connexin43_CGap junction alpha-1 protein (Cx43), C terminal
2697CXA1_HUMANP17302IPR013092Connexin_NConnexin, N terminal

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