Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2706
Official Symbol:GJB2
Other Aliases:CX26|DFNA3|DFNB1|HID|KID|NSRD1|PPK
See related:HGNC:4284|MIM:121011|HPRD:00413
Chromosome:13
Location:13q11-q12
Gene Description:gap junction protein, beta 2, 26kDa (connexin 26)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0158
ORGANISM:human
Entrez Gene ID:2706
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.75 :: 1.90 :: 1.22 :: 0.76 :: -2.52 :: -1.95 :: -2.76
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14619CBCerebellum100.084.974006652832
14619CTXCerebral cortex100.085.435604095459
14619HIPHippocampal region86.308597564697382.3153190612793
14619HPFHippocampal formation93.381206512451284.6810722351074
14619HYHypothalamus75.745157241821365.6047534942627
14619LSXLateral septal complex90.499073028564571.3367786407471
14619MBMidbrain71.358951568603566.6523246765137
14619MYMedulla82.911178588867276.6389083862305
14619OLFOlfactory bulb100.092.3791160583496
14619PPons80.318634033203173.0376319885254
14619PALPallidum73.449918746948264.713098526001
14619RHPRetrohippocampal region100.087.0801963806152
14619sAMYStriatum-like amygdalar nuclei83.092811584472769.0586109161377
14619STRStriatum82.254550933837967.5733604431152
14619STRdStriatum dorsal region79.379606246948265.9710302352905
14619STRvStriatum ventral region91.258239746093871.7810535430908
14619THThalamus76.533948898315468.2403774261475
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2706GO:0005886TASComponentplasma membrane
2706GO:0005922TASComponentconnexon complex
2706GO:0006810TASProcesstransport
2706GO:0007267TASProcesscell-cell signaling
2706GO:0007605TASProcesssensory perception of sound
2706GO:0015285TASFunctionconnexon channel activity
2706GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003995.2--OCP1HPRD00413
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2706CXB2_HUMANP29033IPR000500ConnexinConnexins
2706CXB2_HUMANP29033IPR002268Connexin26Gap junction beta-2 protein (Cx26)
2706CXB2_HUMANP29033IPR013092Connexin_NConnexin, N terminal

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