Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:27244
Official Symbol:SESN1
Other Aliases:MGC138241|PA26|RP11-787I22.1|SEST1
See related:HGNC:21595|MIM:606103|HPRD:07310
Chromosome:6
Location:6q21
Gene Description:sestrin 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0124
ORGANISM:human
Entrez Gene ID:27244
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:140742
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
140742CBCerebellum76.009531021118285.4965782165527
140742CTXCerebral cortex84.176696777343877.7611293792725
140742HIPHippocampal region73.011442184448298.1114654541016
140742HPFHippocampal formation75.209972381591891.7278251647949
140742HYHypothalamus18.640162944793715.5913004875183
140742LSXLateral septal complex52.125998497009348.2374086380005
140742MBMidbrain23.060429573059121.9960432052612
140742MYMedulla31.478520393371635.8071784973145
140742OLFOlfactory bulb78.583656311035280.4396095275879
140742PPons21.00956058502222.87864112854
140742PALPallidum21.984557151794419.7860298156738
140742RHPRetrohippocampal region78.626289367675877.9336204528809
140742sAMYStriatum-like amygdalar nuclei47.386678695678738.2258787155151
140742STRStriatum49.670974731445340.6252737045288
140742STRdStriatum dorsal region47.828562736511238.3870420455933
140742STRvStriatum ventral region55.757308959960946.3762836456299
140742THThalamus31.340226173400929.8218364715576
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
27244GO:0005634TASComponentnucleus
27244GO:0006974TASProcessresponse to DNA damage stimulus
27244GO:0007050TASProcesscell cycle arrest
27244GO:0008285TASProcessnegative regulation of cell proliferation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
27244IPR006730PA26PA26 p53-induced protein (sestrin)

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