Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2729
Official Symbol:GCLC
Other Aliases:GCS|GLCL|GLCLC
See related:HGNC:4311|MIM:606857|HPRD:06032
Chromosome:6
Location:6p12
Gene Description:glutamate-cysteine ligase, catalytic subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0582
ORGANISM:human
Entrez Gene ID:2729
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25283
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0143
ORGANISM:human
Entrez Gene ID:2729
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0144
ORGANISM:human
Entrez Gene ID:2729
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14629CBCerebellum25.849594116210935.4701957702637
14629CTXCerebral cortex73.851409912109460.1972885131836
14629HIPHippocampal region47.311359405517663.4438552856445
14629HPFHippocampal formation56.758003234863364.2508163452148
14629HYHypothalamus56.393844604492250.3637046813965
14629LSXLateral septal complex82.532386779785269.159065246582
14629MBMidbrain38.526592254638739.9891777038574
14629MYMedulla46.453918457031259.9253120422363
14629OLFOlfactory bulb84.118217468261775.1429672241211
14629PPons43.121334075927754.7733993530273
14629PALPallidum65.80748748779365.5706405639648
14629RHPRetrohippocampal region81.796493530273471.6303787231445
14629sAMYStriatum-like amygdalar nuclei91.439239501953175.2058410644531
14629STRStriatum89.673416137695373.8408660888672
14629STRdStriatum dorsal region84.218536376953167.7735900878906
14629STRvStriatum ventral region100.092.0039138793945
14629THThalamus50.988319396972752.3866424560547
KARG Evidence 4
KARG ID:QTL0143
Trait:cocaine related behaviol
Peak:42
Peak Marker:D9Ncvs47
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
KARG Evidence 5
KARG ID:QTL0144
Trait:morphine antinociception
Peak:42
Peak Marker:D9Mit8
Parents:C57BL/6J x DBA/2J)F2 intercross; BXD (B = C57BL/6J, D = DBA/2J) (RI)
Evidence ID:11420618
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2729GO:0003676IEAFunctionnucleic acid binding
2729GO:0004357TASFunctionglutamate-cysteine ligase activity
2729GO:0006534TASProcesscysteine metabolism
2729GO:0006536TASProcessglutamate metabolism
2729GO:0006750IEAProcessglutathione biosynthesis
2729GO:0008015TASProcesscirculation
2729GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2729GSH1_HUMANP48506IPR004308GCSGlutamate-cysteine ligase catalytic subunit

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