Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:273
Official Symbol:AMPH
Other Aliases:AMPH1
See related:HGNC:471|MIM:600418|HPRD:02687
Chromosome:7
Location:7p14-p13
Gene Description:amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0293
ORGANISM:human
Entrez Gene ID:273
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.54
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
218038CBCerebellum91.576854705810590.0296821594238
218038CTXCerebral cortex100.0100.0
218038HIPHippocampal region100.0100.0
218038HPFHippocampal formation100.0100.0
218038HYHypothalamus84.040050506591882.3202133178711
218038LSXLateral septal complex70.204185485839857.3790149688721
218038MBMidbrain90.0379333496094100.0
218038MYMedulla88.3242797851562100.0
218038OLFOlfactory bulb100.0100.0
218038PPons89.0234718322754100.0
218038PALPallidum81.048610687255991.6282958984375
218038RHPRetrohippocampal region100.0100.0
218038sAMYStriatum-like amygdalar nuclei81.883075714111385.5469245910645
218038STRStriatum46.871797561645542.9196109771729
218038STRdStriatum dorsal region35.353769302368233.3515491485596
218038STRvStriatum ventral region53.400928497314542.4593849182129
218038THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
273GO:0005515IEAFunctionprotein binding
273GO:0005737IEAComponentcytoplasm
273GO:0006897TASProcessendocytosis
273GO:0007268TASProcesssynaptic transmission
273GO:0008021TASComponentsynaptic vesicle
273GO:0015629TASComponentactin cytoskeleton
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7448NP_000629.2vitronectin precursorHPRD01902
-1759NP_004399.1dynamin 1HPRD03851
-6853NP_008881.2synapsin I isoform IaHPRD02433
-23523NP_036427.1calcineurin binding protein 1HPRD10369
-51100NP_057093.1SH3-containing protein SH3GLB1HPRD15333
NP_001626.1--AP 2 alpha C subunitHPRD02687
NP_001626.1---BIND133315
NP_001626.11759-Dynamin 1HPRD02687
NP_001626.16853-Synapsin IHPRD02687
NP_001626.123523-Calcineurin binding protein 1HPRD02687
NP_001626.151100-SH3 domain GRB2 like endophilin B1HPRD02687
NP_001626.17448-VitronectinHPRD02687
NP_001626.15338NP_002654.2phospholipase D2HPRD02687
NP_001626.15338NP_002654.2phospholipase D2HPRD03857
NP_001626.16456NP_003017.1SH3-domain GRB2-like 2HPRD02687
NP_001626.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1HPRD02687
NP_001626.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1HPRD04586
NP_001626.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1BIND133314
NP_001626.18867NP_003886.2synaptojanin 1 isoform aHPRD02687
NP_001626.11213NP_004850.1clathrin heavy chain 1HPRD02687
NP_001626.11213NP_004850.1clathrin heavy chain 1HPRD00350
NP_001626.1274NP_647593.1bridging integrator 1 isoform 1HPRD02687
NP_001626.1274NP_647593.1bridging integrator 1 isoform 1HPRD03150
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
273IPR003005AmphiphysinAmphiphysin
273IPR003017Amphiphysin_1Amphiphysin, isoform 1
273IPR004148BARBAR
273IPR000694PRO_richProline-rich region
273IPR001452SH3Src homology-3
273AMPH_HUMANP49418IPR003005AmphiphysinAmphiphysin
273AMPH_HUMANP49418IPR003017Amphiphysin_1Amphiphysin, isoform 1
273AMPH_HUMANP49418IPR004148BARBAR
273AMPH_HUMANP49418IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
273AMPH_HUMANP49418IPR000694PRO_richProline-rich region
273AMPH_HUMANP49418IPR001452SH3Src homology-3

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