Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2730
Official Symbol:GCLM
Other Aliases:GLCLR
See related:HGNC:4312|MIM:601176|HPRD:03106
Chromosome:1
Location:1p22.1
Gene Description:glutamate-cysteine ligase, modifier subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0614
ORGANISM:human
Entrez Gene ID:2730
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29739
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14630CBCerebellum47.197891235351662.4629859924316
14630CTXCerebral cortex92.419525146484478.8561172485352
14630HIPHippocampal region53.968681335449283.9790878295898
14630HPFHippocampal formation72.498458862304788.4001083374023
14630HYHypothalamus18.821611404418916.126522064209
14630LSXLateral septal complex9.164747238159186.40114736557007
14630MBMidbrain21.887514114379923.8080940246582
14630MYMedulla44.252864837646559.8887710571289
14630OLFOlfactory bulb79.930969238281273.8162307739258
14630PPons29.15850448608438.6090888977051
14630PALPallidum33.085216522216834.0239295959473
14630RHPRetrohippocampal region100.096.4845962524414
14630sAMYStriatum-like amygdalar nuclei54.109138488769543.167366027832
14630STRStriatum40.985382080078132.7042083740234
14630STRdStriatum dorsal region45.309844970703136.9972610473633
14630STRvStriatum ventral region28.022451400756820.4679584503174
14630THThalamus16.438802719116216.0962238311768
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2730GO:0004357IEAFunctionglutamate-cysteine ligase activity
2730GO:0006534TASProcesscysteine metabolism
2730GO:0006750IEAProcessglutathione biosynthesis
2730GO:0016491IEAFunctionoxidoreductase activity
2730GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2730GSH0_HUMANP48507

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