Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:27344
Official Symbol:PCSK1N
Other Aliases:PROSAAS|SAAS
See related:HGNC:17301|MIM:300399|HPRD:02320
Chromosome:X
Location:Xp11.23
Gene Description:proprotein convertase subtilisin/kexin type 1 inhibitor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0069
ORGANISM:human
Entrez Gene ID:27344
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:0.27 :: -0.39 :: 0.06 :: 0.18 :: -0.45 :: 0.35 :: -0.40 :: -0.22 :: -0.42 :: -0.41
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
30052CBCerebellum21.867322921752927.6083488464355
30052CTXCerebral cortex65.800732612609958.4991264343262
30052HIPHippocampal region70.241487503051870.8673343658447
30052HPFHippocampal formation80.162742614746176.7654247283936
30052HYHypothalamus100.0100.0
30052LSXLateral septal complex58.867708206176853.6092429161072
30052MBMidbrain91.037288665771593.5215263366699
30052MYMedulla98.1444091796875100.0
30052OLFOlfactory bulb75.660882949829171.9451389312744
30052PPons100.0100.0
30052PALPallidum84.682697296142689.2817878723145
30052RHPRetrohippocampal region83.282157897949278.2730655670166
30052sAMYStriatum-like amygdalar nuclei100.0100.0
30052STRStriatum43.455300331115736.8493432998657
30052STRdStriatum dorsal region21.400734901428216.6902899742126
30052STRvStriatum ventral region56.931241989135740.6868095397949
30052THThalamus53.971132278442449.5589122772217
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
27344IPR010832ProSAASProSAAS

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