Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:274
Official Symbol:BIN1
Other Aliases:AMPH2|AMPHL|DKFZp547F068|MGC10367|SH3P9
See related:HGNC:1052|MIM:601248|HPRD:03150
Chromosome:2
Location:2q14
Gene Description:bridging integrator 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0328
ORGANISM:human
Entrez Gene ID:274
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:30948
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
30948CBCerebellum100.0100.0
30948CTXCerebral cortex100.0100.0
30948HIPHippocampal region100.0100.0
30948HPFHippocampal formation100.0100.0
30948HYHypothalamus100.0100.0
30948LSXLateral septal complex100.0100.0
30948MBMidbrain100.0100.0
30948MYMedulla100.0100.0
30948OLFOlfactory bulb100.0100.0
30948PPons100.0100.0
30948PALPallidum100.0100.0
30948RHPRetrohippocampal region100.0100.0
30948sAMYStriatum-like amygdalar nuclei100.0100.0
30948STRStriatum100.0100.0
30948STRdStriatum dorsal region100.0100.0
30948STRvStriatum ventral region100.0100.0
30948THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
274GO:0005515IEAFunctionprotein binding
274GO:0005634IEAComponentnucleus
274GO:0005737IEAComponentcytoplasm
274GO:0007049IEAProcesscell cycle
274GO:0008283TASProcesscell proliferation
274GO:0015629TASComponentactin cytoskeleton
274GO:0030100IEAProcessregulation of endocytosis
274GO:0030154IEAProcesscell differentiation
274GO:0045786IEAProcessnegative regulation of progression through cell cycle
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5338NP_002654.2phospholipase D2HPRD03857
-6456NP_003017.1SH3-domain GRB2-like 2HPRD05125
-8491NP_003609.2mitogen-activated protein kinase kinase kinase kinase 3HPRD05373
-8867NP_003886.2synaptojanin 1 isoform aHPRD09182
-1759NP_004399.1dynamin 1HPRD03851
-3675NP_005492.1integrin alpha 3 isoform b, precursorHPRD05431
-5747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
-6853NP_008881.2synapsin I isoform IaHPRD02433
-51100NP_057093.1SH3-containing protein SH3GLB1HPRD15333
-3672NP_852478.1integrin, alpha 1 precursorHPRD01892
NP_647593.1--ClathrinHPRD03150
NP_647593.1--Alpha integrin-6BHPRD03150
NP_647593.1--Alpha-3B integrinHPRD03150
NP_647593.1--c-MycHPRD03150
NP_647593.1--p73betaHPRD03150
NP_647593.1--RIN3HPRD03150
NP_647593.11759-Dynamin 1HPRD03150
NP_647593.18867-Synaptojanin 1HPRD03150
NP_647593.16456-SH3 containing GRB2 like protein 2HPRD03150
NP_647593.13672-Integrin alpha 1HPRD03150
NP_647593.13675-Integrin alpha 3HPRD03150
NP_647593.15338-Phospholipase D2HPRD03150
NP_647593.16853-Synapsin IHPRD03150
NP_647593.18491-MAP4K3HPRD03150
NP_647593.151100-SH3 domain GRB2 like endophilin B1HPRD03150
NP_647593.15747-FAKHPRD03150
NP_647593.18723NP_003785.1sorting nexin 4HPRD03150
NP_647593.18723NP_003785.1sorting nexin 4HPRD09334
NP_647593.154453NP_061866.1RAB5 interacting protein 2HPRD03150
NP_647593.154453NP_061866.1RAB5 interacting protein 2HPRD15249
NP_647593.179890NP_079108.3Ras and Rab interactor 3HPRD03150
NP_647593.179890NP_079108.3Ras and Rab interactor 3HPRD11494
NP_647593.1274NP_647593.1bridging integrator 1 isoform 1HPRD03150
NP_647598.1-CAB46677.1polyproteinBIND180343
NP_647600.1-CAB46677.1polyproteinBIND180344
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
274IPR003005AmphiphysinAmphiphysin
274IPR003023Amphiphysin_2Amphiphysin, isoform 2
274IPR004148BARBAR
274IPR000875CecropinCecropin
274IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
274IPR003072NOR1_rcptOrphan nuclear receptor, NOR1 type
274IPR000694PRO_richProline-rich region
274IPR001452SH3Src homology-3
274IPR011511SH3_2Variant SH3
274BIN1_HUMANO00499IPR003005AmphiphysinAmphiphysin
274BIN1_HUMANO00499IPR003023Amphiphysin_2Amphiphysin, isoform 2
274BIN1_HUMANO00499IPR004148BARBAR
274BIN1_HUMANO00499IPR000875CecropinCecropin
274BIN1_HUMANO00499IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
274BIN1_HUMANO00499IPR000694PRO_richProline-rich region
274BIN1_HUMANO00499IPR001452SH3Src homology-3
274BIN1_HUMANO00499IPR011511SH3_2Variant SH3

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