Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2745
Official Symbol:GLRX
Other Aliases:GRX|GRX1|MGC117407
See related:HGNC:4330|MIM:600443|HPRD:02707
Chromosome:5
Location:5q14
Gene Description:glutaredoxin (thioltransferase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0209
ORGANISM:human
Entrez Gene ID:2745
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
93692CBCerebellum6.355365037918098.19821763038635
93692CTXCerebral cortex10.44682431221019.25894784927368
93692HIPHippocampal region11.284623146057113.3329420089722
93692HPFHippocampal formation9.4486410617828410.4018321037292
93692HYHypothalamus2.680498421192172.99076515436172
93692LSXLateral septal complex0.4044155925512310.334686689078808
93692MBMidbrain5.364271044731147.25209748744965
93692MYMedulla11.898942470550520.5575075149536
93692OLFOlfactory bulb5.947079062461855.24359691143036
93692PPons7.3888707160949711.5970747470856
93692PALPallidum3.230831861495973.65563559532166
93692RHPRetrohippocampal region7.709924936294567.56228703260422
93692sAMYStriatum-like amygdalar nuclei1.037900045514110.951824486255646
93692STRStriatum0.7210235893726350.622989073395729
93692STRdStriatum dorsal region0.4688479155302050.40305133908987
93692STRvStriatum ventral region1.440101474523541.15677937865257
93692THThalamus13.274465322494513.892911195755
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2745GO:0006118IEAProcesselectron transport
2745GO:0015038TASFunctionglutathione disulfide oxidoreductase activity
2745GO:0045454IEAProcesscell redox homeostasis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002055.14217NP_005914.1mitogen-activated protein kinase kinase kinase 5HPRD02707
NP_002055.14217NP_005914.1mitogen-activated protein kinase kinase kinase 5HPRD03904
NP_002055.14217NP_005914.1mitogen-activated protein kinase kinase kinase 5BIND262381
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2745GLRX1_HUMANP35754IPR011767GLR_ASGlutaredoxin active site
2745GLRX1_HUMANP35754IPR002109GlutaredoxinGlutaredoxin
2745GLRX1_HUMANP35754IPR006663Thioredox_dom2Thioredoxin domain 2

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