Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2746
Official Symbol:GLUD1
Other Aliases:GDH|GLUD|MGC132003
See related:HGNC:4335|MIM:138130|HPRD:11748
Chromosome:10
Location:10q23.3
Gene Description:glutamate dehydrogenase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0534
ORGANISM:human
Entrez Gene ID:2746
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24399
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0202
ORGANISM:human
Entrez Gene ID:2746
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
KARG Evidence 3
KARG ID:QTL0202
Trait:METH responses for body temperature
Peak:15.5
Peak Marker:Glud
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2746GO:0000166IEAFunctionnucleotide binding
2746GO:0004353IEAFunctionglutamate dehydrogenase [NAD(P)+] activity
2746GO:0005524IEAFunctionATP binding
2746GO:0005525IEAFunctionGTP binding
2746GO:0005739IEAComponentmitochondrion
2746GO:0006520IEAProcessamino acid metabolism
2746GO:0006538TASProcessglutamate catabolism
2746GO:0007169NASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
2746GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_005262.1--MAP3K1HPRD11748
NP_005262.18655-Dynein light chain 1HPRD11748
NP_005262.12806NP_002071.1aspartate aminotransferase 2 precursorHPRD11748
NP_005262.19020NP_003945.1mitogen-activated protein kinase kinase kinase 14HPRD11748
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2746DHE3_HUMANP00367IPR006095GLFV_DHGlu/Leu/Phe/Val dehydrogenase
2746DHE3_HUMANP00367IPR006096GLFV_DH_CGlu/Leu/Phe/Val dehydrogenase, C terminal
2746DHE3_HUMANP00367IPR006097GLFV_DH_NGlu/Leu/Phe/Val dehydrogenase, dimerisation region

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