Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2770
Official Symbol:GNAI1
Other Aliases:Gi
See related:HGNC:4384|MIM:139310|HPRD:00756
Chromosome:7
Location:7q21
Gene Description:guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0500
ORGANISM:human
Entrez Gene ID:2770
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25686
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14677CBCerebellum46.645408630371196.8194999694824
14677CTXCerebral cortex100.0100.0
14677HIPHippocampal region81.2914772033691100.0
14677HPFHippocampal formation98.9605827331543100.0
14677HYHypothalamus73.177078247070371.4002952575684
14677LSXLateral septal complex100.0100.0
14677MBMidbrain69.728557586669974.1422080993652
14677MYMedulla67.764429092407281.085521697998
14677OLFOlfactory bulb100.0100.0
14677PPons58.610088348388766.0654048919678
14677PALPallidum91.9710311889648100.0
14677RHPRetrohippocampal region100.0100.0
14677sAMYStriatum-like amygdalar nuclei100.0100.0
14677STRStriatum74.946105957031272.5481758117676
14677STRdStriatum dorsal region47.643724441528342.853588104248
14677STRvStriatum ventral region97.582004547119181.9581565856934
14677THThalamus67.424390792846768.3341274261475
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2770GO:0000166IEAFunctionnucleotide binding
2770GO:0004871IEAFunctionsignal transducer activity
2770GO:0005515IPIFunctionprotein binding
2770GO:0005525IEAFunctionGTP binding
2770GO:0007165IEAProcesssignal transduction
2770GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6001AAH09361.1Regulator of G-protein signaling 10, isoform aHPRD04172
-3356NP_000612.15-hydroxytryptamine (serotonin) receptor 2AHPRD01638
-4988NP_000905.1opioid receptor, mu 1HPRD02484
-6752NP_001041.1somatostatin receptor 2HPRD01674
-6753NP_001042.1somatostatin receptor 3HPRD01675
-9294NP_004221.1endothelial differentiation, sphingolipid G-protein-coupled receptor, 5HPRD05488
-2825NP_005270.2G protein-coupled receptor 1HPRD02585
-5999NP_005604.1regulator of G-protein signaling 4HPRD03947
-10287NP_005864.1G protein signalling regulator 19HPRD05461
-10636NP_006471.2regulator of G-protein signalling 14HPRD03944
-59340NP_067637.2histamine H4 receptorHPRD06004
-60626NP_068751.4resistance to inhibitors of cholinesterase 8 homolog AHPRD12373
-53637NP_110387.1endothelial differentiation, sphingolipid G-protein-coupled receptor, 8HPRD05510
-64407NP_570138.1regulator of G-protein signalling 18HPRD06224
-6002NP_937872.1regulator of G-protein signalling 12 isoform 1HPRD03943
NP_002060.3--RASD1HPRD00756
NP_002060.36752-Somatostatin receptor 2HPRD00756
NP_002060.36753-Somatostatin receptor 3HPRD00756
NP_002060.310287-Regulator of G protein signaling 19HPRD00756
NP_002060.36001-Regulator of G protein signaling 10HPRD00756
NP_002060.35999-Regulator of G protein signaling 4HPRD00756
NP_002060.39294-Endothelial differentiation gene 5HPRD00756
NP_002060.359340-Histamine H4 receptorHPRD00756
NP_002060.353637-Endothelial differentiation gene 8HPRD00756
NP_002060.310636-Regulator of G protein signaling 14HPRD00756
NP_002060.36002-Regulator of G protein signaling 12HPRD00756
NP_002060.33356-Serotonin 5-HT-2A receptorHPRD00756
NP_002060.364407-Regulator of G protein signaling 18HPRD00756
NP_002060.34988-Opioid receptor mu 1HPRD00756
NP_002060.32825-G protein coupled receptor 1HPRD00756
NP_002060.34935NP_000264.1G protein-coupled receptor 143HPRD02355
NP_002060.34935NP_000264.1G protein-coupled receptor 143HPRD00756
NP_002060.33480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00932
NP_002060.33480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00756
NP_002060.36000NP_002915.2regulator of G-protein signalling 7HPRD03948
NP_002060.36000NP_002915.2regulator of G-protein signalling 7HPRD00756
NP_002060.36801NP_003153.2striatin, calmodulin binding proteinHPRD18124
NP_002060.32864NP_005294.1G protein-coupled receptor 40HPRD04822
NP_002060.32864NP_005294.1G protein-coupled receptor 40HPRD00756
NP_002060.363940NP_071390.1G-protein signalling modulator 3 (AGS3-like, C. elegans)HPRD13605
NP_002060.44926NP_006176.1nuclear mitotic apparatus protein 1BIND183868
NP_002060.429899NP_037428.2G-protein signalling modulator 2 (AGS3-like, C. elegans)BIND183869
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2770GNAI1_HUMANP63096IPR002975Fungi_GproteinAFungal G-protein, alpha subunit
2770GNAI1_HUMANP63096IPR000469Gprotein_alpha12G-protein alpha subunit, group 12
2770GNAI1_HUMANP63096IPR001019Gprotein_alph_bdGuanine nucleotide binding protein (G-protein), alpha subunit
2770GNAI1_HUMANP63096IPR001408Gprotein_alpha_IG-protein alpha subunit, group I
2770GNAI1_HUMANP63096IPR001806Ras_trnsfrmngRas GTPase
2770GNAI1_HUMANP63096IPR006036TrkA_KuptakeTrkA potassium uptake protein

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